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TranscriptomicsTLR4 ligands LPS and MPLA differentially regualte effector and memory CD8 T cell differentiation
Here we implemented a simple dendritic cell (DC)-mediated immunization approach to study the effects of commonly used adjuvants, Toll like receptor (TLR) ligands, on effector CD8 T cell differentiation and memory T cell development. To our surprise, we found that the TLR4 ligand LPS was far more sup...
ORGANISM(S): Mus musculus 
2014-06-03 | E-GEOD-50764 | biostudies-arrayexpress
ProteomicsProteomic expression profiles in exosomes of bovine mammary epithelial cell line MAC-T infected with Staphylococcus aureus
A comprehensive comparison analysis of proteins in exosomes derived from S. aureus-infected (SA group) and normal MAC-T cells (C group) was performed using a shotgun proteomic by DIA approach.
ORGANISM(S): Bos Taurus 
2022-10-09 | PXD037220 |
ProteomicsLabel-free proteome analysis of small extracellular vesicles (sEV) expressing different HRS mutants.
Label-free proteome analysis of small extracellular vesicles (sEV) derived from WM9 cells expressing different HRS mutants: wild type (HRSWT), phospho-deficient (HRSS345A), and phospho-mimetic mutant HRS (HRSS345D).
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-02-16 | MSV000088846 | MassIVE
TranscriptomicsGenome-wide analysis of gene expression of Th1 and Tfh LCMV-specific Smarta CD4 T cell populations
In this study, we sought to distinguish phenotypically and functionally distinct virus-specific effector CD4 T cell subsets that form during acute lymphocytic choriomeningitis virus (LCMV) infection and to examine their ability to develop into memory T cells. To further characterize the effector su...
ORGANISM(S): Mus musculus 
2011-10-04 | E-GEOD-32596 | biostudies-arrayexpress
ModelsHardiansyah2019 - QSP model of chimeric antigen receptor T-Cell therapy
This QSP model explains how the mechanism of action connects to the clinical outcomes and, therefore, may serve as an important model-based platform to guide the development and personalized dosing of the CART therapy.
2025-01-15 | MODEL2009230001 | BioModels
ProteomicsUbiquitin Thioesterase OTUB2 is An Endoplasmic Reticulum Stress-associated β Cell Autoantigen Targeted by CD8+ T cells in Type 1 Diabetes
Autoreactive CD8+ T cell plays a key role in the pathogenesis of Type 1 diabetes (T1D), but the antigen spectrum that activate autoreactive CD8+ T cells is still not completely clear. Endoplasmic reticulum stress（ERS）has been implicated in the generation of β cell autoantigens and the enhanced immun...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-24 | PXD041227 | Pride
Otub2 Endoplasmic reticulum stress Type 1 diabetes Cd8+ t-cell. 
UnknownDistal Lck Promoter-Driven Cre Shows Cell Type-Specific Function in Innate-like T Cells.
Not available
S-EPMC8612026 | biostudies-literature
UnknownT-cell dysfunction in natural killer/T-cell lymphoma.
Not available
S-EPMC10210841 | biostudies-literature
UnknownMicrofluidic-prepared DOTAP nanoparticles induce strong T-cell responses in mice.
Not available
S-EPMC6980563 | biostudies-literature
ProteomicsTargeting LRBA triggers CTLA4 degradation and antitumor immunity for cancer immunotherapy
The lipopolysaccharide-responsive beige-like anchor protein (LRBA) deficiency causes severe autoimmune diseases and cytotoxic T-lymphocyte-associated protein 4 (CTLA4) loss in humans. However, the impact of LRBA on antitumor immunity remains understudied. Here, we identified the role of LRBA in anti...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-23 | PXD064363 | Pride
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