Sort   by:  
 Page size 
ProteomicsCellular Validation of Chemically Improved Inhibitor Identifies Monoubiquitination on OTUB2
Ubiquitin thioesterase OTUB2, a cysteine protease from the ovarian tumor (OTU) deubiquitinase superfamily, is associated with enhanced expression during tumor progression and metastasis. Development of OTUB2 inhibitors is therefore believed to be therapeutically important, yet potent and selective s...
ORGANISM(S): Homo sapiens (Human) 
2023-06-27 | PXD041346 | Pride
Otub2 Small-molecule inhibitor Monoubiquitination 
GenomicsThe Deubiquitinating Enzyme Otub2 Modulates Pancreatic Beta-Cells Function and Survival
The Deubiquitinating Enzyme Otub2 Modulates Pancreatic Beta-Cells Function and Survival
PRJNA1207084 | ENA
GenomicsAnalysis of the differential expression of genes in Otub2- knockout mice
Analysis of the differential expression of genes in Otub2- knockout mice
PRJNA721314 | ENA
GenomicsSoybean derived phosphatidylserine synthetically targets OTUB2 epigenetic silencing in squamous cell carcinoma
Soybean derived phosphatidylserine synthetically targets OTUB2 epigenetic silencing in squamous cell carcinoma
PRJNA721679 | ENA
TranscriptomicsThe Deubiquitinating Enzyme Otub2 Modulates Pancreatic Beta-Cells Function and Survival
We have previously shown that otubain 2 (OTUB2), a deubiquitinating enzyme, inhibits caspase-3/7 activity in primary human islets; promotes insulin secretion and inhibits cytokine-induced nuclear factor-κB (NFκB) activity. In the present work we show that overexpression of Otub2 in MIN6 cells inhibi...
ORGANISM(S): Mus musculus 
2026-03-25 | GSE285973 | GEO
GenomicsOTUB2 silencing promotes ovarian cancer via mitochondrial metabolic reprogramming and can be synthetically targeted by CA9 inhibition
OTUB2 silencing promotes ovarian cancer via mitochondrial metabolic reprogramming and can be synthetically targeted by CA9 inhibition
PRJNA973945 | ENA
UnknownThe deubiquitinase OTUB2 promotes cervical cancer growth through stabilizing FOXM1.
Not available
S-EPMC10839374 | biostudies-literature
TranscriptomicsOTUB2 silencing promotes ovarian cancer via mitochondrial metabolic reprogramming and can be synthetically targeted by CA9 inhibition
These findings delineate the mechanism of OTUB2 epigenetic silencing in ovarian cancer, demonstrate the critical roles of OTUB2/SNX29P2 in inhibiting glycolysis and eliciting cuproptosis in cancer cells and suggest that CA9 inhibitor treatment is a promising therapeutic option for OTUB2-silenced tum...
ORGANISM(S): Homo sapiens 
2024-04-19 | GSE232772 | GEO
UnknownCellular Validation of a Chemically Improved Inhibitor Identifies Monoubiquitination on OTUB2.
Not available
S-EPMC10510154 | biostudies-literature
UnknownDeubiquitination of RIPK3 by OTUB2 potentiates neuronal necroptosis after ischemic stroke.
Not available
S-EPMC11982199 | biostudies-literature
Sort   by:  
 Page size