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ProteomicsMass Spectrometry Proteomics Reveals Cell Density Affects Drug Treatment Efficacy
using proteomic data to explain the difference induced by cultured cell confluence
ORGANISM(S): Homo Sapiens 
2022-08-18 | PXD036142 |
ProteomicsMulti-omics study for drug resistance investigation
Palbociclib is a specific CDK4/6 inhibitor that has been widely applied in multiple tumor types. Different from cytotoxic drugs, the anticancer mechanism of palbociclib mainly depends on cell cycle inhibition. Therefore, the resistance mechanism is different. For clinical cancer patients, drug resis...
ORGANISM(S): Homo Sapiens 
2022-11-30 | PXD038509 |
ProteomicsComparative Analysis of Soybean Seed Proteome Based on Different Mass Spectrometry Acquisition Strategies
This study established a soybean seed proteome database and analyzed the raw mass spectrometry data of BoxCar and DIA on MaxQuant based on this database. Subsequently, the three mass spectrometry acquisition strategies, DDA, DIA and BoxCar, were compared for their depth of protein identification, da...
ORGANISM(S): Glycine Max 
2024-05-16 | PXD052278 |
ProteomicsArginine GlcNAcylation of Rab small GTPases by the pathogen Salmonella Typhimurium
We determined the GlcNAcyaltion of Rab1 by a Salmonella T3SS effector SseK3. IP experiments were performed from HEK293 cells and MS files were acquired on Q Exactive mass spectrometer. We analysed the differences of protein abundance, comparing the normalized intensity on distinct proteins from diff...
ORGANISM(S): Homo Sapiens Escherichia Coli Mus Musculus 
2020-06-05 | PXD019062 |
ProteomicsProxitome profiling of a viral suppressors of RNA silencing identifies the DEAD-box RNA helicase RH20 as a positive regulator of antiviral RNA interference in Nicotiana benthamiana
In the prolonged arms race between viruses and their host plants, viruses usually encode viral suppressors of RNA silencing (VSR) to overcome the hosts' defense mechanism by inhibiting RNAi. Barley stripe mosaic virus (BSMV) is an RNA virus characterized by a positive single-stranded genetic structu...
ORGANISM(S): Nicotiana Benthamiana 
2024-02-20 | PXD049705 |
ProteomicsThe Lin28b/Wnt5a axis drives pancreas cancer through crosstalk between cancer associated fibroblasts and tumor epithelium
Bidirectional signal transduction between tumor epithelial cells and tumor microenvironment (TME) is important for tumor development. Here we showed that Lin28b/let-7 pathway is indispensable for modulating the expression of Wnt5a in tumor epithelium, which could be secreted and then up-regulates Li...
ORGANISM(S): Mus Musculus 
2023-09-19 | PXD045477 |
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