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GenomicsGenome-wide characterization of menin-dependent H3K4me3 reveals a specific role for menin in the regulation of genes implicated in MEN1-like tumors (ChIP-Seq)
Inactivating mutations in the MEN1 gene predisposing to the multiple endocrine neoplasia type 1 (MEN1) syndrome can also cause sporadic pancreatic endocrine tumors. MEN1 encodes menin, a subunit of MLL1/MLL2-containing histone methyltransferase complexes that trimethylate histone H3 at lysine 4 (H3K...
ORGANISM(S): Mus musculus 
2012-06-01 | E-GEOD-37774 | biostudies-arrayexpress
TranscriptomicsGenome-wide characterization of menin-dependent H3K4me3 reveals a specific role for menin in the regulation of genes implicated in MEN1-like tumors
This SuperSeries is composed of the following subset Series: GSE37774: Genome-wide characterization of menin-dependent H3K4me3 reveals a specific role for menin in the regulation of genes implicated in MEN1-like tumors (ChIP-Seq) GSE37775: Genome-wide characterization of menin-dependent H3K4me3 reve...
ORGANISM(S): Mus musculus 
2012-05-31 | E-GEOD-37776 | biostudies-arrayexpress
GenomicsUBR5 Mediates Menin Inhibitor Dependent Menin/KMT2A Complex Stability [ChIP-seq]
UBR5 Mediates Menin Inhibitor Dependent Menin/KMT2A Complex Stability [ChIP-seq]
PRJNA1272575 | ENA
GenomicsUBR5 Mediates Menin Inhibitor Dependent Menin/KMT2A Complex Stability [RNA-seq]
UBR5 Mediates Menin Inhibitor Dependent Menin/KMT2A Complex Stability [RNA-seq]
PRJNA1272588 | ENA
ProteomicsComparison of protein expression alterations in Menin inhibitor-sensitive and tolerant/resistant AML cells with or without Menin inhibitor treatment
AML MV4-11, OCI-AML3 and Menin inhibitor tolerant resistant MV4-11-MITR, and OCI-AML3-MITR cells were treated with 500 nM of SNDX-50469 for 48 hours to determine the global protein expression alterations that correlate with the tolerant/resistant phenotype compared to parental controls as well as th...
ORGANISM(S): Homo sapiens (Human) 
2026-09-03 | PXD053575 | Pride
Epigenetics Drug resistance Menin inhibitor Aml 
GenomicsEpigenetic Regulation of Non-canonical Menin Targets Modulates Menin Inhibitor Response in Acute Myeloid Leukemia
Epigenetic Regulation of Non-canonical Menin Targets Modulates Menin Inhibitor Response in Acute Myeloid Leukemia
PRJNA1047124 | ENA
GenomicsUpfront Menin-inhibitor resistance in multiply pretreated leukemias
Upfront Menin-inhibitor resistance in multiply pretreated leukemias
PRJNA1363942 | ENA
GenomicsEpigenetic Regulation of Non-canonical Menin Targets Modulates Menin Inhibitor Response in Acute Myeloid Leukemia
Epigenetic Regulation of Non-canonical Menin Targets Modulates Menin Inhibitor Response in Acute Myeloid Leukemia
PRJNA1047125 | ENA
ProteomicsMulti-omics analysis of MEN1 missense mutations identifies disruption of menin-MLL and menin-JunD interactions as critical requirements for molecular pathogenicity
Loss-of-function mutations of the multiple endocrine neoplasia type 1 (MEN1) gene are causal to the MEN1 tumor syndrome, but they are also commonly found in sporadic pancreatic neuroendocrine tumors and other types of cancers. The MEN1 gene product, menin, is involved in transcriptional and chromati...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD031928 | Pride
Greencut&run 
TranscriptomicsDifferentially regulated genes in adipocytes derived from Men1-null vs WT mouse embryonic stem cells
MEN1 is a tumor suppressor gene loss of which causes lipoma (fatty tumors under the skin) and many other endocrine and non-endocrine tumors. It's target genes in fat cells (adipocytes) are unknown. Gene expression in adipocytes that were in vitro differentiated from mouse embryonic stem cells (mES...
ORGANISM(S): Mus musculus 
2016-02-03 | E-GEOD-65859 | biostudies-arrayexpress
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