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TranscriptomicsIdentification of an intrahepatic transcriptional signature associated with self-limiting infection in the woodchuck model of hepatitis B
The woodchuck model of hepatitis B virus (HBV) infection displays many characteristics of human infection and has particular value for characterizing the host immune responses during the development of chronic infection. Using the newly developed custom woodchuck microarray platform, we compared the...
ORGANISM(S): Marmota monax 
2012-09-22 | E-GEOD-37683 | biostudies-arrayexpress
TranscriptomicsTranscriptomic analysis of the woodchuck model of chronic hepatitis B: Liver gene expression in uninfected, resolved and chronically infected woodchucks
The Eastern woodchuck (Marmota monax) is naturally infected with woodchuck hepatitis virus (WHV), a hepadnavirus closely related to the human hepatitis B virus (HBV). The woodchuck is used as an animal model for studying chronic hepatitis B (CHB) and HBV-associated hepatocellular carcinoma (HCC) in ...
ORGANISM(S): Marmota monax 
2012-04-10 | E-GEOD-36533 | biostudies-arrayexpress
TranscriptomicsTranscriptomic analysis of the woodchuck model of chronic hepatitis B: Kidney gene expression in uninfected, resolved and chronically infected woodchucks
The Eastern woodchuck (Marmota monax) is naturally infected with woodchuck hepatitis virus (WHV), a hepadnavirus closely related to the human hepatitis B virus (HBV). The woodchuck is used as an animal model for studying chronic hepatitis B (CHB) and HBV-associated hepatocellular carcinoma (HCC) in ...
ORGANISM(S): Marmota monax 
2012-04-10 | E-GEOD-36541 | biostudies-arrayexpress
TranscriptomicsTranscriptomic analysis of the woodchuck model of chronic hepatitis B: Liver gene expression in tumor and non-tumor samples from chronically infected woodchucks
The Eastern woodchuck (Marmota monax) is naturally infected with woodchuck hepatitis virus (WHV), a hepadnavirus closely related to the human hepatitis B virus (HBV). The woodchuck is used as an animal model for studying chronic hepatitis B (CHB) and HBV-associated hepatocellular carcinoma (HCC) in ...
ORGANISM(S): Marmota monax 
2012-04-10 | E-GEOD-36545 | biostudies-arrayexpress
TranscriptomicsTranscriptomic analysis of the woodchuck model of chronic hepatitis B: Spleen gene expression in uninfected, resolved and chronically infected woodchucks
The Eastern woodchuck (Marmota monax) is naturally infected with woodchuck hepatitis virus (WHV), a hepadnavirus closely related to the human hepatitis B virus (HBV). The woodchuck is used as an animal model for studying chronic hepatitis B (CHB) and HBV-associated hepatocellular carcinoma (HCC) in ...
ORGANISM(S): Marmota monax 
2012-04-10 | E-GEOD-36544 | biostudies-arrayexpress
TranscriptomicsSustained Efficacy and Seroconversion with the Toll-Like Receptor 7 Agonist GS-9620 in the Woodchuck Model of Chronic Hepatitis B
Background & Aims: New therapies for chronic hepatitis B (CHB) are urgently needed since current treatments rarely lead to cure. We evaluated whether the oral small molecule toll-like receptor (TLR7) agonist GS-9620 could induce durable anti-viral efficacy in woodchucks chronically infected with woo...
ORGANISM(S): Marmota monax 
2015-04-16 | E-GEOD-67935 | biostudies-arrayexpress
TranscriptomicsIntrahepatic transcriptional signature associated with response to interferon-a treatment in the woodchuck model of chronic hepatitis B
To define the intrahepatic cellular and molecular characteristics of the antiviral response to wIFN-alpha in woodchuck, the transcriptional profiles of woodchuck liver were studied by using RNASeq Woodchucks liver samples with chronic woodchuck hepatitis virus (WHV) infection were treated with recom...
ORGANISM(S): Marmota monax 
2015-08-07 | E-GEOD-71582 | biostudies-arrayexpress
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