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TranscriptomicsMutation Order Affects Tumor Evolution and Clinical Course of Disease
Background: Cancers result from accumulation of somatic mutations and their properties are thought to reflect the sum of these mutations. However, little is known about the consequences of altering the order of mutation acquisition. Methods: Mutation order was determined in myeloproliferative neopl...
ORGANISM(S): Homo sapiens 
2014-11-17 | E-MTAB-3086 | biostudies-arrayexpress
TranscriptomicsGATA3 acts upstream of FOXA1 in mediating ER binding by shaping enhancer accessibility
Estrogen Receptor (ESR1) drives growth in the majority of human breast cancers by binding to regulatory elements and inducing transcription events that promote tumor growth. Differences in enhancer occupancy by ESR1, contribute to the diverse expression profiles and clinical outcome observed in brea...
ORGANISM(S): Homo sapiens 
2012-11-26 | E-GEOD-39623 | biostudies-arrayexpress
TranscriptomicsRNA interference uncouples the function of a long noncoding RNA product from that of its transcription: HB2 and SUM159 cells
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2015-11-12 | E-GEOD-60563 | biostudies-arrayexpress
TranscriptomicsRNA interference uncouples the function of a long noncoding RNA product from that of its transcription [HB2]
Long noncoding RNAs (lncRNAs) regulate gene expression via their RNA product or through transcriptional interference, yet a strategy to differentiate these two processes is missing. We employed siRNAs to specifically target GNG12-AS1, a lncRNA overlapping the tumour suppressor DIRAS3, transcriptiona...
ORGANISM(S): Homo sapiens 
2015-11-12 | E-GEOD-60562 | biostudies-arrayexpress
TranscriptomicsZNF703 overexpression and/or knockdown in the breast cancer cell line MCF-7
The telomeric amplicon at 8p12 is common in ER+ breast cancers. Array-CGH and expression analyses of 1172 tumors revealed ZNF703/Zeppo1 was the single gene within the minimal amplicon and was amplified predominantly in the Luminal B subtype. Amplification was shown to correlate with increased gene a...
ORGANISM(S): Homo sapiens 
2011-03-26 | E-GEOD-23673 | biostudies-arrayexpress
TranscriptomicsRNA interference uncouples the function of a long noncoding RNA product from that of its transcription [SUM159]
Long noncoding RNAs (lncRNAs) regulate gene expression via their RNA product or through transcriptional interference, yet a strategy to differentiate these two processes is missing. We employed siRNAs to specifically target GNG12-AS1, a lncRNA overlapping the tumour suppressor DIRAS3, transcriptiona...
ORGANISM(S): Homo sapiens 
2015-11-12 | E-GEOD-60561 | biostudies-arrayexpress
GenomicsThe androgen receptor induces a distinct transcriptional program in castration resistant prostate cancer in man
The androgen receptor (AR) is the major transcriptional driver of prostate cell growth in man. For the first time, we define AR targets in prostate cancer (PC) tissue representing progression from treatment-naive to castrate-resistant disease (CRPC). We employed chromatin immunoprecipitation with hi...
ORGANISM(S): Homo sapiens 
2013-01-04 | E-GEOD-28219 | biostudies-arrayexpress
TranscriptomicsPhenotype specific analyses of p53 reveal distinct regulatory mechanism for chronically activated p53
microarray analysis with and without sh-p53 in IMR90 (normal human diploid fiborblasts) Phenotypes were created by overexpression of RasG12V, E1A/RasG12V in IMR90 cells, in growing IMR90, inr quiescent IMR90 cells (3 days confluence) and 24 or 48 hours Etoposide treated IMR90 cells were subjected t...
ORGANISM(S): Homo sapiens 
2015-02-27 | E-GEOD-53379 | biostudies-arrayexpress
GenomicsThe androgen receptor coordinates biosynthesis and proliferation in prostate cancer
The androgen receptor (AR) is the major therapeutic target in prostate cancer, although the important targets of the AR have remained obscure. Here we report a detailed genomic profile of AR signalling and find that the AR directly regulates glycolysis, anabolic metabolism and cell cycle regulators...
ORGANISM(S): Homo sapiens 
2011-03-23 | E-GEOD-28126 | biostudies-arrayexpress
TranscriptomicsmiR-203, a microRNA of multilayered epithelia, inhibits metastatic fitness in human squamous cell carcinoma
The colonization of distant organs by metastatic carcinoma cells underpins most human cancer-related deaths, including those from head and neck squamous cell carcinoma (HNSCC). We report that miR-203, a miRNA that promotes keratinocyte differentiation, is necessary and sufficient to inhibit multiple...
ORGANISM(S): Homo sapiens 
2016-07-03 | E-GEOD-47028 | biostudies-arrayexpress
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