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MetabolomicsTemporal characterization of serum metabolite signatures in lung cancer patients undergoing treatment
Lung cancer causes more deaths in men and women than any other cancer related disease. Currently, few effective strategies exist to predict how patients will respond to treatment. We evaluated the serum metabolomic profiles of 25 lung cancer patients undergoing chemotherapy ± radiation to evaluate t...
2017-01-19 | MTBLS200 | MetaboLights
TranscriptomicsXist RNA is a potent suppressor of hematologic cancer in mice.
X-chromosome aneuploidies have long been associated with human cancers, but causality has not been established. In mammals, X-chromosome inactivation (XCI) is triggered by Xist RNA to equalize gene expression between the sexes. Here we delete Xist in the blood compartment of mice and demonstrate tha...
ORGANISM(S): Mus musculus 
2013-02-20 | E-GEOD-43961 | biostudies-arrayexpress
UnknownUnder phosphate starvation conditions, Fe and Al trigger accumulation of the transcription factor STOP1 in the nucleus of Arabidopsis root cells.
Not available
S-EPMC6852189 | biostudies-literature
MetabolomicsHuman Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice
Autism spectrum disorder (ASD) manifests as alterations in complex human behaviors including social communication and stereotypies. In addition to genetic risks, the gut microbiome differs between typically-developing (TD) and ASD individuals, though it remains unclear whether the microbiome contrib...
2019-07-04 | MTBLS726 | MetaboLights
MetabolomicsMetabolic profiling of rheumatoid arthritis neutrophils reveals altered energy metabolism that is not affected by JAK inhibition
Neutrophils play a key role in the pathophysiology of rheumatoid arthritis (RA) where release of ROS and proteases directly causes damage to joints and tissues. Neutrophil function is directly affected by Janus Kinase (JAK) inhibitor drugs, including tofacitinib and baricitinib, which are clinically...
2023-07-11 | MTBLS4766 | MetaboLights
UnknownTenosynovial Giant Cell Tumor Observational Platform Project (TOPP) Registry: A 2-Year Analysis of Patient-Reported Outcomes and Treatment Strategies.
Not available
S-EPMC10243766 | biostudies-literature
TranscriptomicsTranscriptomic analysis of human retinal detachment (RD) reveals both inflammation and photoreceptor death
We have used surgical specimens to perform a differential analysis of the transcriptome of human retinal tissues following detachment. Data analysis reveals major involvement of the immune response in the disease and interindividual variation was monitored to unravel a second crucial aspect of the p...
ORGANISM(S): Homo sapiens 
2012-03-06 | E-GEOD-28133 | biostudies-arrayexpress
UnknownAmino acid-insensitive mTORC1 regulation enables nutritional stress resilience in hematopoietic stem cells.
Not available
S-EPMC5373863 | biostudies-literature
UnknownA Requirement for Zic2 in the Regulation of Nodal Expression Underlies the Establishment of Left-Sided Identity.
Not available
S-EPMC6041270 | biostudies-literature
UnknownA Novel Analog Reasoning Paradigm: New Insights in Intellectually Disabled Patients.
Not available
S-EPMC4771701 | biostudies-literature
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