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TranscriptomicsRNA-seq of Dand5 KO and WT mESC
DAND5 is an extracellular protein belonging to the family of TGF-β/Nodal signaling antagonists Cerberus/DAN. Loss-of-function of DAND5 in mice leads to a massive increase of the ventricular heart wall’s thickness caused by an increased mitotic index of the CMs at the compact myocardium. To clarify t...
ORGANISM(S): Mus musculus 
2021-03-26 | E-MTAB-9986 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling of severe spinal muscular atrophy mouse embryonic stem cell-derived motor neurons
Proximal spinal muscular atrophy (SMA) is an early onset, autosomal recessive motor neuron disease caused by loss of or mutation in SMN1 (survival motor neuron 1). Despite understanding the genetic basis underlying this disease, it is still not known why motor neurons (MNs) are selectively affected ...
ORGANISM(S): Mus musculus 
2014-09-08 | E-GEOD-56284 | biostudies-arrayexpress
TranscriptomicsAICAR can modulate the expression of microRNA in J1 mESC
We have demonstrated AICAR can maintain J1 mouse ES cells pluripotency in our previous research, yet its effects on ES cells miRNAs expression remain a mystery. In this study, we performed small RNA (sRNA) High-throughput sequencing using Illumina HiSeq 2000 to investigate the influence of AICAR on ...
ORGANISM(S): Mus musculus 
2014-02-06 | E-GEOD-54586 | biostudies-arrayexpress
TranscriptomicsSequential stage specific reporter line analysis (SSRLA) of 3 BAC transgenic mESC lines
FACS purified cells from differentiation day 14-15 cells from 3 BAC transgenic mESC lines: Hes::GFP (early), Nurr1::GFP (mid), and Pitx3::YFP (late) DA neuron development reporter lines All three lines were differentiated towards the midbrain dopamine phenotype, and FACS purification was performed ...
ORGANISM(S): Mus musculus 
2012-07-11 | E-GEOD-37446 | biostudies-arrayexpress
GenomicsRNAseq & Smad and Foxh1 ChIpseq in pluripotent mESC and EBs
RNAseq & Smad and Foxh1 ChIpseq in pluripotent mESC and EBs
PRJNA515268 | ENA
GenomicsRole of Prdm14 in mouse embryonic stem cells: ChIP-seq and RNA-seq analyses
Prdm14 is a PR-domain and zinc-finger protein whose expression is restricted to the pluripotent cells of an early embryo, embryonic stem cells (ESCs), and germ cells. Here we show that Prdm14 safeguards mouse ESC maintenance by preventing induction of extraembryonic endoderm (ExEn) fates. Conversely...
ORGANISM(S): Mus musculus 
2010-12-23 | E-GEOD-25409 | biostudies-arrayexpress
Genomics
Screen for activity of 14-nt sgRNA in mESC
PRJNA1127704 | ENA
TranscriptomicsSix in situ Hi-C libraries of control and mESC auxin-inducible degrons for Scc1 and Ring1b.
In this experiment, we've examined chromatin conformation differences of E14 mESC against cohesin and Ring1b degrons. We performed a modified in situ Hi-C protocol from (Rao et al., 2014) that can be found in detail at (Díaz et al., 2018). Samples were digested with MboI restriction enzyme. The aim ...
ORGANISM(S): Mus musculus 
2020-01-23 | E-MTAB-7816 | biostudies-arrayexpress
GenomicsChIP seq of mESC treated with doxorubicin
mESC were treated with doxorubicin and then histone modifications or p53 binding sites were analyzed
ORGANISM(S): Mus musculus 
2021-05-21 | GSE168688 | GEO
TranscriptomicsSequential stage specific reporter line analysis (SSRLA) of 3 BAC transgenic mESC lines
FACS purified cells from differentiation day 14-15 cells from 3 BAC transgenic mESC lines: Hes::GFP (early), Nurr1::GFP (mid), and Pitx3::YFP (late) DA neuron development reporter lines
ORGANISM(S): Mus musculus 
2012-07-12 | GSE37446 | GEO
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