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ProteomicsIntegrative metabolomics, proteomics and transcriptomics analysis reveals liver toxicity of mesoporous silica nanoparticles
As pharmaceutical excipients, mesoporous silica nanoparticles (MSNs) have attracted considerable concern based on potential risks to the public. The impact of MSNs on biochemical metabolism is poorly understood, and few studies have compared the effects of MSNs administered via different routes. To ...
ORGANISM(S): Mus musculus (Mouse) 
2022-01-06 | PXD030757 | Pride
Proteomics Mesoporous silica nanoparticle Metabolomics Hepatotoxicity Inflammation Transcriptomic Oxidative stress Oxidative phosphorylation. 
GenomicsCell signaling pathways modulation in silica nanoparticle-saturated macrophages
Cell signaling pathways modulation in silica nanoparticle-saturated macrophages
PRJNA1375529 | ENA
TranscriptomicsCell signaling pathways modulation in silica nanoparticle-saturated macrophages
In this study, we studied RAW 264.7 macrophages saturated with silica nanoparticles (SNPs) of different size (50 and 100 nm), porosity (nonporous, mesoporous), density (solid, mesoporous, and hollow), and surface composition (hydrophobicity) at their maximum non-toxic concentrations to study the cha...
ORGANISM(S): Mus musculus 
2026-04-01 | GSE312613 | GEO
GenomicsControlled Nutrient Delivery to Pancreatic Islets Using Polydopamine-Coated Mesoporous Silica Nanoparticles
Controlled Nutrient Delivery to Pancreatic Islets Using Polydopamine-Coated Mesoporous Silica Nanoparticles
PRJNA1035764 | ENA
UnknownEndolysosomal Mesoporous Silica Nanoparticle Trafficking along Microtubular Highways.
Not available
S-EPMC8781846 | biostudies-literature
TranscriptomicsControlled Nutrient Delivery to Pancreatic Islets Using Polydopamine-Coated Mesoporous Silica Nanoparticles
In the present study, we designed a nanoscale platform for the sustained and controlled delivery of nutrients to pancreatic islets-upon transplantation. Our platform consists of a mesoporous silica nanoparticle (MSNP), loaded with glutamine (G), an essential amino acid required for islet survival an...
ORGANISM(S): Mus musculus 
2023-12-04 | GSE247020 | GEO
UnknownOne-Pot Approach to Prepare Organo-silica Hybrid Capillary Monolithic Column with Intact Mesoporous Silica Nanoparticle as Building Block.
Not available
S-EPMC5048148 | biostudies-literature
UnknownOptoacoustic imaging identifies ovarian cancer using a microenvironment targeted theranostic wormhole mesoporous silica nanoparticle.
Not available
S-EPMC6289590 | biostudies-literature
UnknownMesoporous silica nanoparticle delivery of chemically modified siRNA against TWIST1 leads to reduced tumor burden.
Not available
S-EPMC4587301 | biostudies-literature
UnknownDelivery of ricin toxin a-chain by peptide-targeted mesoporous silica nanoparticle-supported lipid bilayers.
Not available
S-EPMC4119887 | biostudies-literature
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