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ProteomicsMesothelioma-associated fibroblasts enhance proliferation and migration of malignant pleural mesothelioma cells via Met/PI3K and WNT signaling but do not protect against cisplatin_Secreted proteins
Introduction: Malignant pleural mesothelioma (MPM) is an aggressive malignancy with poor prognosis. Unlike many other cancers, MPM is mostly characterized by inactivation of tumor suppressor genes. Its highly malignant nature in absence of tumor driving oncogene mutations indicates an extrinsic supp...
ORGANISM(S): Homo sapiens (Human) 
2023-06-20 | PXD035987 | Pride
Human malignant pleural mesothelioma-associated fibroblasts (cafs) High-resolution timstof-based proteomics analyses Cisplatin 
ProteomicsMesothelioma-associated fibroblasts enhance proliferation and migration of malignant pleural mesothelioma cells via Met/PI3K and WNT signaling but do not protect against cisplatin_Cytoplasmic proteins
Introduction: Malignant pleural mesothelioma (MPM) is an aggressive malignancy with poor prognosis. Unlike many other cancers, MPM is mostly characterized by inactivation of tumor suppressor genes. Its highly malignant nature in absence of tumor driving oncogene mutations indicates an extrinsic supp...
ORGANISM(S): Homo sapiens (Human) 
2023-06-20 | PXD036017 | Pride
Human malignant pleural mesothelioma-associated fibroblasts (cafs) High-resolution timstof-based proteomics analyses Cisplatin 
ProteomicsPrimary and hTERT-transduced mesothelioma-associated fibroblasts but not primary or hTERT-transduced mesothelial cells stimulate growth of human mesothelioma cells_Secreted proteins
Introduction: Pleural mesothelioma (PM) is known as one of the most aggressive malignancies among all cancers, despite of usually absent tumor-driver mutations in oncogenes. It develops in a unique inflammatory tumor microenvironment (TME), which has been postulated as major contributor of PM’s high...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD043511 | Pride
Htert Mesothelioma-associated fibroblasts Pleural mesothelial cells Pleural mesothelioma Conditioned medium Human telomerase reverse transcriptase Tumor microenvironment 
ProteomicsMesothelioma-associated fibroblasts enhance proliferation and migration of malignant pleural mesothelioma cells via Met/PI3K and WNT signaling but do not protect against cisplatin_Proteins from nuclear extracts
Introduction: Malignant pleural mesothelioma (MPM) is an aggressive malignancy with poor prognosis. Unlike many other cancers, MPM is mostly characterized by inactivation of tumor suppressor genes. Its highly malignant nature in absence of tumor driving oncogene mutations indicates an extrinsic supp...
ORGANISM(S): Homo sapiens (Human) 
2023-06-19 | PXD036127 | Pride
Human malignant pleural mesothelioma-associated fibroblasts (cafs) High-resolution timstof-based proteomics analyses Cisplatin 
ProteomicsPrimary and hTERT-transduced mesothelioma-associated fibroblasts but not primary or hTERT-transduced mesothelial cells stimulate growth of human mesothelioma cells_ Cytoplasmic proteins & Proteins from nuclear extracts
Introduction: Pleural mesothelioma (PM) is known as one of the most aggressive malignancies among all cancers, despite of usually absent tumor-driver mutations in oncogenes. It develops in a unique inflammatory tumor microenvironment (TME), which has been postulated as major contributor of PM’s high...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD043534 | Pride
Htert Mesothelioma-associated fibroblasts Pleural mesothelial cells Pleural mesothelioma Conditioned medium Human telomerase reverse transcriptase Tumor microenvironment 
TranscriptomicsMesothelioma-associated fibroblasts enhance proliferation and migration of malignant pleural mesothelioma cells via Met/PI3K and WNT signaling but do not protect against cisplatin
Malignant pleural mesothelioma (MPM) is an aggressive malignancy with poor prognosis. Unlike many other cancers, MPM is mostly characterized by inactivation of tumor suppressor genes. Its highly malignant nature in absence of tumor driving oncogene mutations indicates an extrinsic supply of stimulat...
ORGANISM(S): Homo sapiens 
2022-12-31 | E-MTAB-12179 | biostudies-arrayexpress
ProteomicsCrosstalk with lung fibroblasts shapes the growth and therapeutic response of mesothelioma cells
Mesothelioma is an aggressive cancer of the mesothelial layer associated with an extensive fibrotic response. The latter is in large part mediated by cancer-associated fibroblasts which mediate tumour progression and poor prognosis. However, understanding of the crosstalk between cancer cells and fi...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD040492 | Pride
Mesothelioma Cancer associated fibroblast Signalling crosstalk Targeted therapy 
TranscriptomicsGene expression changes between primary mesothelioma tumour cells and commercially available cell lines, compared to normal primary mesothelial cells
Malignant mesothelioma (MM) is an aggressive, fatal tumour strongly associated with asbestos exposure. There is an urgent need to improve MM patient outcomes and this requires functionally validated pre-clinical models. Mesothelioma-derived cell lines provide an essential and robust tool widely used...
ORGANISM(S): Homo sapiens 
2018-02-01 | E-MTAB-6351 | biostudies-arrayexpress
UnknownConnective tissue growth factor produced by cancer‑associated fibroblasts correlates with poor prognosis in epithelioid malignant pleural mesothelioma.
Not available
S-EPMC7388423 | biostudies-literature
UnknownExtracellular Vesicles Isolated from Malignant Mesothelioma Cancer-Associated Fibroblasts Induce Pro-Oncogenic Changes in Healthy Mesothelial Cells.
Not available
S-EPMC9604431 | biostudies-literature
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