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UnknownRelationship Between Severity of Ischemia and Coronary Artery Disease for Different Stress Test Modalities in the ISCHEMIA Trial.

Background

The relationship between the extent and severity of stress-induced ischemia and the extent and severity of anatomic coronary artery disease (CAD) in patients with obstructive CAD is multifactorial and includes the intensity of stress achieved, type of testing used, presence and ex...
S-EPMC11658795 | biostudies-literature
UnknownPhysical activity, mediating factors and risk of colon cancer: insights into adiposity and circulating biomarkers from the EPIC cohort.

Background

There is convincing evidence that high physical activity lowers the risk of colon cancer; however, the underlying biological mechanisms remain largely unknown. We aimed to determine the extent to which body fatness and biomarkers of various biologically plausible pathways account ...
S-EPMC6241846 | biostudies-literature
UnknownNational survey of the rat hepatitis E virus in rodents in Spain, 2022 to 2023.
BackgroundRat hepatitis E virus (ratHEV) is an emerging virus causing acute and chronic hepatitis in humans. Rats are the main natural reservoir of this pathogen. Large-scale studies assessing ratHEV circulation in rodents in Spain are lacking.AimWe aimed to determine the prevalence of ratHEV in rat...
S-EPMC11951417 | biostudies-literature
UnknownGenome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3.
We conducted a two-stage genome-wide association study of renal cell carcinoma (RCC) in 3,772 affected individuals (cases) and 8,505 controls of European background from 11 studies and followed up 6 SNPs in 3 replication studies of 2,198 cases and 4,918 controls. Two loci on the regions of 2p21 and ...
S-EPMC3049257 | biostudies-literature
UnknownA genome-wide association study identifies a novel susceptibility locus for renal cell carcinoma on 12p11.23.
Renal cell carcinoma (RCC) is the most lethal urologic cancer. Only two common susceptibility loci for RCC have been confirmed to date. To identify additional RCC common susceptibility loci, we conducted an independent genome-wide association study (GWAS). We analyzed 533 191 single nucleotide polym...
S-EPMC3276284 | biostudies-literature
UnknownEvaluation of human papillomavirus antibodies and risk of subsequent head and neck cancer.

Purpose

Human papillomavirus type 16 (HPV16) infection is causing an increasing number of oropharyngeal cancers in the United States and Europe. The aim of our study was to investigate whether HPV antibodies are associated with head and neck cancer risk when measured in prediagnostic sera.
S-EPMC3709056 | biostudies-literature
UnknownCross-Sectional Study on Zoonotic Bacteria Carriage by Small Ruminants from Portugal's Central Region.
Zoonotic bacteria, namely Campylobacter spp., Escherichia coli, Salmonella spp. and Staphylococcus aureus, are commonly implicated in human infections and can be transmitted from animals to humans through direct contact, the environment or the food chain. The emergence of...
S-EPMC12655204 | biostudies-literature
UnknownPDCD4 regulates axonal growth by translational repression of neurite growth-related genes and is modulated during nerve injury responses.
Programmed cell death 4 (PDCD4) protein is a tumor suppressor that inhibits translation through the mTOR-dependent initiation factor EIF4A, but its functional role and mRNA targets in neurons remain largely unknown. Our work identified that PDCD4 is highly expressed in axons and dendrites of CNS and...
S-EPMC7566564 | biostudies-literature
UnknownDetection and Molecular Characterization of Giardia and Cryptosporidium spp. Circulating in Wild Small Mammals from Portugal.
Cryptosporidium spp. and Giardia spp. are important diarrhea-causing protozoan parasites worldwide that exhibit broad host ranges. Wild small mammals can harbor host-adapted and potentially zoonotic species of both parasites. The aim of this study was to investigate Cryptosporidium<...
S-EPMC9913638 | biostudies-literature
UnknownMitochondrial metabolism directs stemness and differentiation in P19 embryonal carcinoma stem cells.
The relationship between mitochondrial metabolism and cell viability and differentiation in stem cells (SCs) remains poorly understood. In the present study, we compared mitochondrial physiology and metabolism between P19SCs before/after differentiation and present a unique fingerprint of the associ...
S-EPMC4158682 | biostudies-literature
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