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ProteomicsIntegrating metabolic and evolutionary engineering for enhanced propionic acid production under cross stress: a multi-omics perspective
We performed a combination of metabolic engineering (deletion of ldh and poxB and overexpression of mmc) with evolutionary engineering (selection under oxygen stress, acid stress and osmotic stress) in Propionibacterium acidipropionici. The results indicated that the mutants had superior physiologic...
ORGANISM(S): Acidipropionibacterium acidipropionici 
2020-04-27 | PXD016616 | Pride
Omics analysis Cross stress Metabolic and evolutionary engineering Propionibacterium acidipropionici Propionic acid 
MetabolomicsLinking genetic, metabolic and phenotypic diversity 1 among S. cerevisiae strains using multi-omics associations
The selection of bioengineering platform strains and engineering strategies to improve the stress resistance of Saccharomyces cerevisiae remains a pressing need in bio-based chemical production. Thus, a systematic effort to exploit the genotypic and phenotypic diversity to boost yeast’s industrial v...
2019-01-16 | MTBLS780 | MetaboLights
UnknownImproved n-Butanol Production from Clostridium cellulovorans by Integrated Metabolic and Evolutionary Engineering.
Not available
S-EPMC6585503 | biostudies-literature
UnknownEngineering microorganisms based on molecular evolutionary analysis: a succinate production case study.
Not available
S-EPMC4211721 | biostudies-literature
TranscriptomicsThe Repertoire and Dynamics of Evolutionary Adaptations to Controlled Nutrient-Limited Environments in Yeast
The experimental evolution of laboratory populations of microbes provides an opportunity to observe the evolutionary dynamics of adaptation in real time.Until very recently, however, such studies have been limited by our inability to systematically find mutations in evolved organisms.We overcome thi...
ORGANISM(S): Saccharomyces cerevisiae 
2010-05-18 | E-GEOD-13435 | biostudies-arrayexpress
UnknownEvolutionary programming as a platform for in silico metabolic engineering.
Not available
S-EPMC1327682 | biostudies-literature
TranscriptomicsEngineering topology and kinetics of sucrose metabolism in Saccharomyces cerevisiae for improved ethanol yield
Sucrose is a major carbon source for industrial bioethanol production by Saccharomyces cerevisiae. In yeasts, two modes of sucrose metabolism occur: (i) extracellular hydrolysis by invertase, followed by uptake and metabolism of glucose and fructose, and (ii) uptake via sucrose-H+ symport followed b...
ORGANISM(S): Saccharomyces cerevisiae 
2011-09-05 | E-GEOD-30535 | biostudies-arrayexpress
UnknownMetabolic and Evolutionary Engineering of Diploid Yeast for the Production of First- and Second-Generation Ethanol.
Not available
S-EPMC8831863 | biostudies-literature
UnknownTranscriptomics and Proteomics Analyses of the Responses of Propionibacterium acidipropionici to Metabolic and Evolutionary Manipulation.
Not available
S-EPMC7438477 | biostudies-literature
GenomicsPhysiological and Molecular Characterization of an Oxidative Stress-Resistant Saccharomyces cerevisiae Strain Obtained by Evolutionary Engineering
Physiological and Molecular Characterization of an Oxidative Stress-Resistant Saccharomyces cerevisiae Strain Obtained by Evolutionary Engineering
PRJNA767089 | ENA
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