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MetabolomicsIntestinal TM6SF2 Protects Against Metabolic Dysfunction-associated Steatohepatitis through the Gut-Liver Axis

Transmembrane-6 superfamily member 2 (TM6SF2) regulates hepatic fat metabolism and is closely associated with metabolic dysfunction-associated steatohepatitis (MASH). MASH involves genetic predisposition and gut microbiota alteration, yet the role of host-microbes interaction in disease developme...

2024-10-08 | MTBLS11004 | MetaboLights
MetabolomicsDT-109 ameliorates nonalcoholic steatohepatitis in nonhuman primates

Nonalcoholic steatohepatitis (NASH) prevalence is rising with no pharmacotherapy approved. A major hurdle in NASH drug development is the poor translatability of preclinical studies to safe/effective clinical outcomes, and recent failures highlight a need to identify new targetable pathways. Dysr...

2023-04-13 | MTBLS5005 | MetaboLights
ProteomicsMetabolomics and Lipidomics Screening Reveal Reprogrammed Signaling Pathways toward Cancer Development in Non-Alcoholic Steatohepatitis
Non-alcoholic fatty liver disease is now considered the most common form of chronic liver disease. It is a complex metabolic disease that silently progresses into non-alcoholic steatohepatitis (NASH). In fact, NASH is the tipping point for pericellular fibrosis, cirrhosis and hepatocellular carcinom...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-08-19 | MSV000088003 | MassIVE
MetabolomicsInvolvement of the Gut Microbes Romboutsia hominis and Akkermansia muciniphila in the Pathophysiology and Development of Nonalcoholic Steatohepatitis
Background Nonalcoholic steatohepatitis (NASH) represents a growing global health challenge due to its propensity to progress to irreversible hepatic disorders, including fibrosis, cirrhosis, and carcinoma. This study aimed to investigate the role of gut microbiota in the pathogenesis of NASH. We ha...
2025-06-23 | MTBLS12631 | MetaboLights
TranscriptomicsGene expression profiling unravels cancer-related hepatic molecular signatures in steatohepatitis but not in steatosis
Pathogenesis and factors for determining progression of alcoholic and non-alcoholic steatosis to steatohepatitis with risk of further progression to liver cirrhosis and cancer are poorly understood. In the present study, we aimed to identify potential molecular signatures for discrimination of steat...
ORGANISM(S): Homo sapiens 
2012-12-10 | E-GEOD-33814 | biostudies-arrayexpress
MetabolomicsMetabolic Characteristics of Schisantherin B in Mice with Metabolic-Associated Fatty Liver Disease

Objectives: To observe the pharmacokinetic differences of schisantherin B (STB) in the blood and liver of normal and metabolic-associated fatty liver disease (MAFLD) mice, as well as the changes in CYP450 enzymes in MAFLD mice. Methods: A MAFLD model was established in C57 mice fed with a high-fa...

2025-10-29 | MTBLS13232 | MetaboLights
MetabolomicsA comprehensive multiomic analysis reveals metabolic reprogramming underlying human Fontan-associated liver disease

BACKGROUND: Single ventricle congenital heart disease (SVCHD) is a severe form of cardiac malformation in which there is only one functional ventricle. The Fontan operation is the current standard of care for SVCHD. Almost all patients who have undergone the Fontan operation develop liver fibrosi...

2024-12-13 | MTBLS10782 | MetaboLights
ProteomicsmARC1 knockdown protects liver from diet-induced NASH in mouse
Human genetic studies have identified several MARC1 variants as protective against non-alcoholic fatty liver diseases (NAFLD). The MARC1 variants are associated with reduced lipid profiles, liver enzymes, and liver-related mortality. However, the role of mitochondrial amidoxime reducing component 1 ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-04-28 | MSV000091820 | MassIVE
TranscriptomicsTranscription profiling of rat non-alcoholic Steatohepatitis following feeding of high polyunsaturated fat diets
Most commonly used models of non-alcoholic steatohepatitis (NASH) are diets based on specific gene knockouts or represent extreme manipulations of diet. We have examined the effects of modest increased caloric intake and high dietary unsaturated fat content on the development of NASH in male rats us...
ORGANISM(S): Rattus norvegicus 
2008-06-20 | E-GEOD-8253 | biostudies-arrayexpress
MetabolomicsPenthorum chinense Pursh Ameliorates Metabolic Dysfunction-Associated Alcohol-Related Liver Disease through Gut Microbiota Modulation and Metabolic Remodeling
Metabolic dysfunction-associated alcohol-related liver disease (MetALD) is characterized by hepatic steatosis, oxidative stress, inflammation, and gut microbiota dysbiosis resulting from the coexistence of metabolic dysfunction and alcohol consumption. Penthorum chinense Pursh is a traditional edibl...
2026-06-10 | MTBLS14735 | MetaboLights
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