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MetabolomicsEffects of Platycodins Folium on Depression in Mice Based on a UPLC-Q/TOF-MS Serum Assay and Hippocampus Metabolomics
Major depressive disorder (MDD), also known as depression, is a state characterized by low mood and aversion to activity. Platycodins Folium (PF) is the dried leaf of Platycodon grandiflorum, with anti-inflammatory and antioxidative activities. Our previous research suggested that PF was rich in fla...
2020-06-03 | MTBLS952 | MetaboLights
MetabolomicsAltered metabolome and microbiome features provide clues in understanding irritable bowel syndrome and depression comorbidity

Irritable bowel syndrome (IBS) is one of the functional gastrointestinal disorders characterized by chronic and/or recurrent symptoms of abdominal pain and irregular defecation. Changed gut microbiota has been proposed to mediate IBS; however, contradictory results exist, and IBS-specific microbi...

2021-12-01 | MTBLS2774 | MetaboLights
MetabolomicsBioinspired Nanozyme-Exoskeletonized Yeast-derived Polysaccharides for Treating Comorbid Anxiety and Depression in Inflammatory Bowel Disease

Inflammatory bowel disease (IBD) is a chronic condition frequently accompanied by psychological comorbidities, such as anxiety and depression. Although current treatments may alleviate some of these symptoms, the intricate pathogenesis of these comorbidities highlights an urgent need for the deve...

2026-03-24 | MTBLS14127 | MetaboLights
TranscriptomicsMolecular regulation in the hippocampal dentate gyrus in the onset and treatment of depression
Major depression is a multidimensional disorder highly prevalent in modern society. Although several classes of antidepressants (ADs) are currently available to treat depression, the effectiveness of treatment is still limited, as many patients do not show full remission; thus, there is a need to fi...
ORGANISM(S): Rattus norvegicus 
2015-07-02 | E-GEOD-56028 | biostudies-arrayexpress
TranscriptomicsExpression data from human brain anterior cingulate cortex - including control samples and samples with major depression disorders (26 samples BA25_F)
Major depressive disorder is a heterogeneous illness with a mostly uncharacterized pathology. Large scale gene expression (transcriptome) analysis and genome-wide association studies (GWAS) for single nucleotide polymorphisms have generated a considerable amount of gene- and disease-related informat...
ORGANISM(S): Homo sapiens 
2014-05-16 | E-GEOD-54571 | biostudies-arrayexpress
TranscriptomicsExpression data from human brain anterior cingulate cortex - including control samples and samples with major depression disorders (24 samples BA25_M)
Major depressive disorder is a heterogeneous illness with a mostly uncharacterized pathology. Large scale gene expression (transcriptome) analysis and genome-wide association studies (GWAS) for single nucleotide polymorphisms have generated a considerable amount of gene- and disease-related informat...
ORGANISM(S): Homo sapiens 
2014-05-16 | E-GEOD-54572 | biostudies-arrayexpress
TranscriptomicsExpression data from human brain amygdala - including control samples and samples with major depression disorders (42 samples MD3_AMY)
Major depressive disorder is a heterogeneous illness with a mostly uncharacterized pathology. Large scale gene expression (transcriptome) analysis and genome-wide association studies (GWAS) for single nucleotide polymorphisms have generated a considerable amount of gene- and disease-related informat...
ORGANISM(S): Homo sapiens 
2014-05-16 | E-GEOD-54564 | biostudies-arrayexpress
TranscriptomicsExpression data from human brain amygdala - including control samples and samples with major depression disorders (28 samples MD1_AMY)
Major depressive disorder is a heterogeneous illness with a mostly uncharacterized pathology. Large scale gene expression (transcriptome) analysis and genome-wide association studies (GWAS) for single nucleotide polymorphisms have generated a considerable amount of gene- and disease-related informat...
ORGANISM(S): Homo sapiens 
2014-05-16 | E-GEOD-54566 | biostudies-arrayexpress
TranscriptomicsExpression data from human brain dorsolateral prefrontal cortex - including control samples and samples with major depression disorders (28 samples BA9_M)
Major depressive disorder is a heterogeneous illness with a mostly uncharacterized pathology. Large scale gene expression (transcriptome) analysis and genome-wide association studies (GWAS) for single nucleotide polymorphisms have generated a considerable amount of gene- and disease-related informat...
ORGANISM(S): Homo sapiens 
2014-05-16 | E-GEOD-54567 | biostudies-arrayexpress
TranscriptomicsExpression data from human brain dorsolateral prefrontal cortex - including control samples and samples with major depression disorders (26 samples NY_BA9)
Major depressive disorder is a heterogeneous illness with a mostly uncharacterized pathology. Large scale gene expression (transcriptome) analysis and genome-wide association studies (GWAS) for single nucleotide polymorphisms have generated a considerable amount of gene- and disease-related informat...
ORGANISM(S): Homo sapiens 
2014-05-16 | E-GEOD-54570 | biostudies-arrayexpress
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