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TranscriptomicsINDUCTION OF OXIDATIVE STRESS AND METAL BINDING GENES IN HUMAN ALVEOLAR MACROPHAGES EXPOSED TO FINE PARTICLES
Exposure to particulate matter (PM) is consistently associated with increased morbidity and mortality attributable in part to respiratory illnesses. The alveolar macrophage (AM) is one of the cell types in the lung constantly exposed to and activated by ambient pollutants. Upon contact with environm...
ORGANISM(S): Homo sapiens 
2008-05-01 | E-GEOD-10394 | biostudies-arrayexpress
ProteomicsNucleosome binding by the pioneer transcription factor OCT4
The nucleosome is a fundamental unit of chromatin in eukaryotes, and generally prevents the binding of transcription factors to genomic DNA. Pioneer transcription factors overcome the nucleosome barrier, and bind their target DNA sequences in chromatin. OCT4 is a representative pioneer transcription...
ORGANISM(S): Homo Sapiens (human) 
2020-05-13 | PXD019160 | JPOST Repository
TranscriptomicsMycobacterial cells have dual nickel-cobalt sensors: sequence-relationships and metal-sites of metal-responsive repressors are not congruent.
A novel ArsR-SmtB family transcriptional repressor, KmtR, has been characterised from mycobacteria. Mutants of M. tuberculosis lacking kmtR show elevated expression of Rv2025c encoding a deduced CDF-family metal-exporter. KmtR-dependent repression of the cdf and kmtR operator-promoters was alleviate...
ORGANISM(S): Mycobacterium tuberculosis 
2007-09-17 | E-BUGS-49 | biostudies-arrayexpress
ProteomicsRiPP DTT Reduction & Metal binding
RiPP has the potential to binding metal. Investigating the type of metal this binds is key
ORGANISM(S): None 
2024-08-14 | MSV000095600 | MassIVE
Transcriptomicsmetal stress 2
Effect of mild metal ion - stress (500µM AlCl3, 500µM VCl3, 1.5mM ZnCl2) on cellular metabolism, resp. on transcription - 30min incubation in yeast Saccharomyces cerevisiae (JSwt - is a FY derivate; MATaleu2ura3trp1HIS3)
ORGANISM(S): Saccharomyces cerevisiae 
2011-05-01 | E-MEXP-2987 | biostudies-arrayexpress
Transcriptomicsmetal stress 1
Effect of mild metal ion-stress (40µM AgNO3, 200µM AsCl3, 2µM CdCl2, 100µM CoCl2, 30µM HgCl2, 1.5mM MnCl2, 1.5mM NiSO4) on cellular metabolism, resp. on transcription - 30min incubation in yeast Saccharomyces cerevisiae
ORGANISM(S): Saccharomyces cerevisiae 
2011-01-01 | E-MEXP-2985 | biostudies-arrayexpress
TranscriptomicsTranscription factor cooperativity in early adipogenic hotspots and super-enhancers
Here we have used a combination of advanced proteomics and genomics approaches to investigate the extent and mechanisms of transcription factor cross-talk at genomic hotspots. We identify ~12,000 transcription factor hotspots in the early phase of adipogenesis, and we find evidence of both simultane...
ORGANISM(S): Mus musculus 
2014-04-17 | E-GEOD-56872 | biostudies-arrayexpress
TranscriptomicsNickel and binary metal mixtures in Daphnia magna after 96h
The recent development of a custom cDNA microarray platform for one of thé standard organisms in aquatic toxicology, Daphnia magna, opened up new ways to mechanistic insights of toxicological responses. In this study, gene expression and (sub)organismal responses (Cellular Energy Allocation, growt...
ORGANISM(S): Daphnia magna 
2010-05-22 | E-GEOD-13866 | biostudies-arrayexpress
MetabolomicsGNPS - RiPP DTT Reduction & Metal binding
RiPP has the potential to binding metal. Investigating the type of metal this binds is key
ORGANISM(S): None 
2024-08-14 | MSV000095600 | GNPS
GenomicsIdentification of Transcription Factor ALR-1::GFP Binding Regions in L2
modENCODE_submission_3156 This submission comes from a modENCODE project of Michael Snyder. For full list of modENCODE projects, see http://www.genome.gov/26524648 Project Goal: We are identifying the DNA binding sites for 300 transcription factors in C. elegans. Each transcription factor gene is ta...
ORGANISM(S): Caenorhabditis elegans 
2011-03-31 | E-GEOD-25787 | biostudies-arrayexpress
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