Nickel and binary metal mixtures in Daphnia magna after 96h

ABSTRACT: The recent development of a custom cDNA microarray platform for one of thé standard organisms in aquatic toxicology, Daphnia magna, opened up new ways to mechanistic insights of toxicological responses. In this study, gene expression and (sub)organismal responses (Cellular Energy Allocation, growth) were assayed after short-term waterborne metal exposure. Microarray analysis of Ni-exposed daphnids revealed several affected functional gene classes, of which the largest ones were involved in different metabolic processes (mainly protein and chitin related processes), cuticula turnover, transport and signal transduction. Furthermore, genes involved in oxygen transport and heme metabolism (hemoglobin, δ-aminolevilunate synthase) were down-regulated. Applying a Partial Least Squares regress

ORGANISM(S): Daphnia magna

SUBMITTER: Tine Vandenbrouck 

PROVIDER: E-GEOD-13866 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress