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MetabolomicsZebrafish Metabolomics: Model for Environmental Metal Toxicity
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ORGANISM(S): Danio rerio 
ST000365 | MetabolomicsWorkbench
MetabolomicsIonomic, Metabolomic, and Enzymatic Responses of the Sea Cucumber Apostichopus japonicus to Single and Combined Salinity and Metal Stress

Desalination brine discharge poses emerging threats to benthic marine organisms through combined salinity stress and metal contamination. This study investigated the individual and combined effects of salinity (35 ppt) and metal exposure (Cu, Fe, and Cd) on the sea cucumber Apostichopus japonicus...

2026-03-18 | MTBLS14079 | MetaboLights
MetabolomicsCadmium acute exposure induces metabolic and transcriptomic perturbations in human mature adipocytes
Obesity is considered as a major public health concern with strong economic and social burdens. Exposure to pollutants such as heavy metals can contribute to the development of obesity and its associated metabolic disorders, including type 2 diabetes and cardiovascular diseases. Adipose tissue is an...
2023-06-29 | MTBLS4128 | MetaboLights
MetabolomicsIntegrated Exposomics/Metabolomics for Rapid Exposure and Effect Analyses

The totality of environmental exposures and lifestyle factors, commonly referred to as the exposome, are poorly understood. Measuring the myriad of chemicals that humans are exposed to is immensely challenging and identifying disrupted metabolic pathways is even more complex. Here, we present a n...

2023-10-26 | MTBLS4556 | MetaboLights
MetabolomicsGut Microbiome and Metabolome Alterations in Mice with Arsenic Exposure and Antibiotic Treatment: Potential Role of Arsenic Biotransformation Genes

Arsenic is the most prevalent toxic metalloid in environment. Evidence of mouse models (germ-free or antibiotic treatment) indicates the gut microbiota’s involvement in the metabolism of ingested arsenic. Linking genes to gut microbial arsenic metabolism with altered toxicity and lifetime in the ...

2025-05-12 | MTBLS11508 | MetaboLights
TranscriptomicsMetal tolerance in brown trout
This study aimed to investigate the transcriptional differences to metal exposure in two populations of Brown trout. These trout were taken from two separate locations, one population with historic exposure to metals and evidence of metal tolerance, and a second population from a clean environment. ...
ORGANISM(S): Salmo trutta 
2024-10-25 | E-MTAB-10209 | biostudies-arrayexpress
Transcriptomicsmetal stress 2
Effect of mild metal ion - stress (500µM AlCl3, 500µM VCl3, 1.5mM ZnCl2) on cellular metabolism, resp. on transcription - 30min incubation in yeast Saccharomyces cerevisiae (JSwt - is a FY derivate; MATaleu2ura3trp1HIS3)
ORGANISM(S): Saccharomyces cerevisiae 
2011-05-01 | E-MEXP-2987 | biostudies-arrayexpress
Transcriptomicsmetal stress 1
Effect of mild metal ion-stress (40µM AgNO3, 200µM AsCl3, 2µM CdCl2, 100µM CoCl2, 30µM HgCl2, 1.5mM MnCl2, 1.5mM NiSO4) on cellular metabolism, resp. on transcription - 30min incubation in yeast Saccharomyces cerevisiae
ORGANISM(S): Saccharomyces cerevisiae 
2011-01-01 | E-MEXP-2985 | biostudies-arrayexpress
TranscriptomicsNickel and binary metal mixtures in Daphnia magna after 96h
The recent development of a custom cDNA microarray platform for one of thé standard organisms in aquatic toxicology, Daphnia magna, opened up new ways to mechanistic insights of toxicological responses. In this study, gene expression and (sub)organismal responses (Cellular Energy Allocation, growt...
ORGANISM(S): Daphnia magna 
2010-05-22 | E-GEOD-13866 | biostudies-arrayexpress
TranscriptomicsINDUCTION OF OXIDATIVE STRESS AND METAL BINDING GENES IN HUMAN ALVEOLAR MACROPHAGES EXPOSED TO FINE PARTICLES
Exposure to particulate matter (PM) is consistently associated with increased morbidity and mortality attributable in part to respiratory illnesses. The alveolar macrophage (AM) is one of the cell types in the lung constantly exposed to and activated by ambient pollutants. Upon contact with environm...
ORGANISM(S): Homo sapiens 
2008-05-01 | E-GEOD-10394 | biostudies-arrayexpress
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