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MetabolomicsMetabolomic Analysis of Candida albicans under Metal-based anti-fungal strategy

Based on a unique pathogen iron interplay mechanism, this work establishes a new therapeutic paradigm targeting iron homeostasis at the host-pathogen interface via sequential metabolic priming, offering a broadly applicable strategy to reprogram resource asymmetry and combat fungal infection.

2026-05-10 | MTBLS13715 | MetaboLights
MetabolomicsResting natural killer cell homeostasis relies on tryptophan/NAD+ metabolism and HIF-1α

Natural killer (NK) cells are forced to cope with different oxygen environments even under resting conditions. The adaptation to low oxygen is regulated by oxygen-sensitive transcription factors, the hypoxia-inducible factors (HIFs). The function of HIFs for NK cell activation and metabolic rewir...

2023-06-01 | MTBLS6863 | MetaboLights
TranscriptomicsInsufficiency of Copper Ion Homeostasis Causes Freeze-Thaw Injury of Yeast Cells
Saccharomyces cerevisiae is exposed to freeze-thaw stress in commercial processes including frozen dough baking. The cell viability and fermentation activity after freeze-thaw were dramatically decreased due to freeze-thaw injury. Because freeze-thaw injury involves complex phenomena, the mechanis...
ORGANISM(S): Saccharomyces cerevisiae 
2009-08-31 | E-GEOD-15461 | biostudies-arrayexpress
TranscriptomicsZinc sensing by metal-responsive transcription factor 1 (MTF1) controls metallothionein and ZnT1 expression to buffer the sensitivity of the transcriptome response to zinc
Only a small number of genes are known direct targets of the zinc-responsive transcription factor MTF1; therefore, the aim of this study was to gain a more complete understanding of the MTF-1 regulated zinc-responsive component of the transcriptome. A targeted siRNA was used to deplete MTF1 express...
ORGANISM(S): Homo sapiens 
2016-02-24 | E-GEOD-76510 | biostudies-arrayexpress
TranscriptomicsExpression data of Arabidopsis thaliana wild-type plants and quadruple nas T-DNA insertion mutants grown under different Fe supply conditions
Essential metals such as iron are required for healthy plant growth. Fe is an important cofactor and catalytic element in many biological processes. Fe and other metals can also be toxic when present in excess. Therefore plants have mechanisms of metal homeostasis which involve coordination of metal...
ORGANISM(S): Arabidopsis thaliana 
2010-09-25 | E-GEOD-24348 | biostudies-arrayexpress
ProteomicsCSF-1R regulates metal ion homeostasis in the brain – implications for neurodegenerative disease
Dominant inactivating mutations in the colony stimulating factor-1 receptor (CSF1R) cause an adult-onset neurodegenerative disease associated with white matter loss and axonal degeneration designated CSF-1R related leukoencephalopathy (CRL), that is modeled in the Csf1r+/- mouse. CRL is caused by mi...
ORGANISM(S): Homo sapiens (Human) 
2026-02-18 | PXD067561 | Pride
Microglia dysfunction Oligodendrocyte stress Metallothionein mt1 Metal ion homeostasis Metallothionein mt3 Csf-1r signaling Csf1r-related leukoencephalopathy Mitochondrial dysfunction Ros Oxidative stress Neurodegeneration Single-nucleus rna sequencing 
MetabolomicsSingle-cell Transcriptomics and Time-series Metabolite Profiling Reveal the Spatiotemporal Regulation of Flavonoid Biosynthesis Genes and Phytohormone Homeostasis by PAP1 in Arabidopsis
Understanding the spatiotemporal regulation of specialized metabolism in plants is critical for advancing both basic plant biology and biotechnological applications. In this study, we utilized single-cell RNA sequencing (scRNA-seq) and time-series metabolite profiling to investigate the regulation o...
2025-05-27 | MTBLS12459 | MetaboLights
TranscriptomicsTwo transcription factors are necessary for iron homeostasis in a salt-dwelling archaeon [ChIP-chip data]
Because iron toxicity and deficiency are equally life threatening, maintaining intracellular iron levels within a narrow optimal range is critical for nearly all known organisms. However, regulatory mechanisms that establish homeostasis are not well understood in organisms that dwell in environments...
ORGANISM(S): Halobacterium sp. NRC-1 
2011-06-02 | E-GEOD-29705 | biostudies-arrayexpress
GenomicsSNP genotyping data in genes related to trace element homeostasis
In this study we provide data regarding sample charactheristics and genotypes in 150 human samples of European origin for SNPs located around genes related to metal homeostasis. SNPs were genotyped with the Illumina VeraCode technology (192-plex format). The genotyped SNPs were used to identify quan...
EGAS00001001292 | EGA
UnknownTobacco as an efficient metal accumulator.
Not available
S-EPMC10082116 | biostudies-literature
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