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TranscriptomicsHeavy metal resistance in Cupriavidus metallidurans CH34 is governed by an intricate transcriptional network.
Background: The high number of heavy metal resistance genes in the soil bacterium Cupriavidus metallidurans CH34 makes it an interesting model organism to study microbial responses to heavy metals. Results: In this study the transcriptional response of this bacterium was measured after challenging i...
ORGANISM(S): Cupriavidus metallidurans CH34 
2011-06-28 | E-GEOD-23876 | biostudies-arrayexpress
MetabolomicsGlobal Analyses of Selective Insulin Resistance in Hepatocytes due to Palmitate Lipotoxicity
Obesity is tightly linked to hepatic steatosis and insulin resistance. One feature of this association is the paradox of selective insulin resistance: insulin fails to suppress hepatic gluconeogenesis but activates lipid synthesis in the liver. How lipid accumulation interferes selectively with some...
2018-04-26 | MTBLS582 | MetaboLights
MetabolomicsOriginal data of bacterial antibiotic resistance lipidomics
Plasmid-mediated dissemination of mcr genes has severely compromised colistin efficacy, necessitating adjuvants that restore antibacterial potency without exacerbating toxicity. Despite their essential roles in bacterial survival and virulence, metal ion acquisition systems remain underexplored as t...
2026-08-13 | MTBLS15318 | MetaboLights
TranscriptomicsExpression analysis of Cupriavidus metallidurans CH34 in presence of heavy metals
Cupriavidus metallidurans CH34 is a metal resistant beta-proteobacterium. The genome of this bacterium contain many genes involved in heavy metal resistance. Gene expression of C. metallidurans was studied after the addition of of Zn(II), Cd(II), Cu(II), Ni(II), Pb(II), Hg(II) or Co(II). Keywords: H...
ORGANISM(S): Ralstonia metallidurans CH34 
2010-06-11 | E-GEOD-7272 | biostudies-arrayexpress
ProteomicsMembrane-associated effluxosomes coordinate multi-metal resistance in Mycobacterium tuberculosis
Bacterial pathogens must withstand metal-induced stress during infection, yet the mechanisms by which they sense and respond to toxic metal ions remain incompletely understood. Here, we uncover a previously unrecognized mechanism in Mycobacterium tuberculosis, the causative agent of tuberculosis, wh...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2025-12-15 | PXD070650 | Pride
Metal binding Tuberculosis Native ms 
TranscriptomicsRNA-seq analysis of the effect of kanamycin and the ABC transporter AtWBC19 on Arabidopsis thaliana seedlings reveals changes in metal content
Plants are exposed to antibiotics produced by soil microorganisms but little is known about their responses at the transcriptional level. Likewise, few endogenous mechanisms of antibiotic resistance have been reported. The Arabidopsis thaliana ATP Binding Cassette (ABC) transporter AtWBC19 (ABCG19) ...
ORGANISM(S): Arabidopsis thaliana 
2014-06-20 | E-GEOD-58662 | biostudies-arrayexpress
ProteomicsUpregulation of the AcrAB2NodT efflux pump confers antibiotic resistance at the cost of collateral metal sensitivity
Bacterial resistance to antibiotics (AB) such as β-lactams, fluoroquinolones, and aminoglycosides often emerges through mutations that alter AB targets, reduce membrane permeability, or increase the activity of AB-modifying enzymes and efflux pumps. Yet the physiological costs associated with AB res...
ORGANISM(S): Caulobacter vibrioides 
2026-03-02 | PXD067190 | Pride
Antibiotics Heavy metals Metal sensitivity Stress response Caulobacter Efflux pumps Antibiotic resistance Copper 
TranscriptomicsMycobacterial cells have dual nickel-cobalt sensors: sequence-relationships and metal-sites of metal-responsive repressors are not congruent.
A novel ArsR-SmtB family transcriptional repressor, KmtR, has been characterised from mycobacteria. Mutants of M. tuberculosis lacking kmtR show elevated expression of Rv2025c encoding a deduced CDF-family metal-exporter. KmtR-dependent repression of the cdf and kmtR operator-promoters was alleviate...
ORGANISM(S): Mycobacterium tuberculosis 
2007-09-17 | E-BUGS-49 | biostudies-arrayexpress
GenomicsThe function of heavy metals in the co-selection of plasmid-borne metal and antibiotic resistance genes in industrially contaminated sediments
Heavy metal and antibiotic resistance plasmids
PRJEB97704 | ENA
MetabolomicsCYP51A1-mediated alkaliptosis resistance is a targetable vulnerability in pancreatic cancer

Alkaliptosis, a pH-dependent form of regulated cell death characterized by impaired lysosomal function and lethal alkalinization, holds promise as a target for cancer therapy. Here, we utilize mass spectrometry-based drug target, transcriptomic screens, and lipid metabolomics to explore the metab...

2025-02-28 | MTBLS9288 | MetaboLights
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