Metalloproteinases

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Unknown (3448)
Transcriptomics (387)
Genomics (191)
Proteomics (95)
Metabolomics (28)
Models (7)
Clinical (3)
Methylation profiling (1)
Other (1)

Organisms

Homo sapiens (192)
Mus musculus (129)
Rattus norvegicus (31)
Danio rerio (12)
Salmo salar (11)
Pimephales promelas (7)
Daphnia magna (5)
synthetic construct (4)
Ambystoma mexicanum (3)
Oryctolagus cuniculus (3)
Hyalella azteca (2)
Macaca mulatta (2)
Aspergillus fumigatus (2)
Bos taurus (2)
Penaeus monodon (2)
Canis lupus familiaris (2)
Sus scrofa (2)
Euarchontoglires (1)
Ampelisca abdita (1)
Myxococcus xanthus (1)
Mytilus edulis (1)
Yarrowia lipolytica (1)
Xenopus laevis (1)
Burkholderia cepacia (1)
Staphylococcus aureus (1)
Oncorhynchus mykiss (1)
Glycine max (1)
Burkholderia cenocepacia (1)
Drosophila melanogaster (1)
Betapolyomavirus macacae (1)

Organisms

Homo sapiens (78)
Mus musculus (60)
Rattus norvegicus (5)
Danio rerio (4)
Oryctolagus cuniculus (2)
Ambystoma mexicanum (2)
Megacormus gertschi (1)
Bothrops neuwiedi (1)
Branchiostoma japonicum (1)
Mus (1)
Penaeus monodon (1)
Canis lupus familiaris (1)
Sus scrofa (1)
Saccharomyces cerevisiae (1)

Repository

biostudies-arrayexpress (246)
ENA (179)
geo (151)
pride (50)
MassIVE (27)
MetaboLights (22)
iProX (9)
BioModels (6)
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jPOST (6)
PanoramaPublic (3)
Cell Collective (1)

Tissue

Fibroblast (8)
Cell culture (7)
Skin (7)
Epithelial cell (3)
Venom (3)
Aorta (2)
Early embryonic cell (2)
Articular cartilage (1)
Blood (1)
Blood plasma (1)
Blood platelet (1)
Bone (1)
Brain (1)
Cardiac muscle cell (1)
Cell line cell (1)
Cerebral gray matter (1)
Chondrocyte (1)
Colon (1)
Culture condition: dark grown cells (1)
Fascia (1)
Fibroblast cell line (1)
HeLa cell (1)
Heart (1)
Keratinocyte (1)
Kidney (1)
Leaf (1)
Liver (1)
Macrophage (1)
Monocyte (1)
Myotube (1)

Disease

Normal (4)
Colorectal Neoplasms (2)
Osteoarthritis (2)
Cartilage disease (1)
Neuroendocrine tumor (1)
Pneumococcal meningitis (1)
Colonic adenocarcinoma (1)
Glioblastoma (1)
Unstable atherosclerotic plaque region (1)
Colorectal cancer (1)
Atherosclerosis (1)
Breast cancer (1)
Cervix carcinoma (1)
Colon cancer (1)
Dilatation of the ascending aorta (1)
Disease free (1)
Influenza (1)
Lung cancer (1)
Multiple sclerosis (1)
Plantar fascial fibromatosis (1)
Platelet storage pool deficiency (1)
Prostate adenocarcinoma (1)
Vector-borne bite transmission (1)

Technology Type

Mass Spectrometry (50)
Shotgun proteomics (33)
Mass spectrometry (13)
Mass spectrometry assay (9)
Data-dependent acquisition (6)
Bottom-up proteomics (5)
Gel-based experiment (4)
Affinity purification coupled with mass spectrometry proteomics (3)
Data-independent acquisition (2)
Top-down proteomics (2)
Illumina MiSeq, Illumina Genome Analyzer IIx (1)

Instrument Platform

Q Exactive (14)
Liquid Chromatography MS - negative - reverse phase (7)
Agilent High resolution C scanner (4)
Illumina HiSeq 2500 (4)
Q Exactive Plus (3)
Illumina HiSeq 2000 (2)
LTQ Orbitrap Velos (2)
LTQ Orbitrap XL (2)
Orbitrap Exploris 480 (2)
Orbitrap Fusion (2)
Q Exactive HF (2)
GeneChip® HT HG-U133+ PM 24-Array Plate (Affymetrix); GeneTitan (Affymetrix) (1)
SensationPlus kit (Affymetrix) (1)
RNeasy Mini Kit (Qiagen); Nanodrop 1000 Spetrophotometer (Thermo Scientific); Agilent 2100 Bioanalyzer (Agilent Technologies) (1)
Affymetrix GeneChip Scanner 3000 7G (1)
Illumina NovaSeq X (1)
Illumina HiSeq X (1)
NextSeq 2000 (1)
HiSeq X Ten (1)
Illumina HiSeq 3000 (1)
Illumina HiSeq 4000 (1)
Xevo G2 XS Tof|1002729 (1)
6545 Q-TOF LC/MS (1)
6546 LC Q-TOF (Agilent Model) (1)
Orbitrap Eclipse (1)
Orbitrap Fusion Lumos (1)
QSTAR Elite (1)
Synapt G2 HDMS (1)
Thermo Scientific Orbitrap Exploris 240 (1)
TripleTOF 5600 (1)

Publication Date

2012 (42)
2010 (41)
2025 (36)
2026 (34)
2013 (33)
2015 (29)
2014 (28)
2017 (27)
2011 (27)
2008 (26)
2023 (25)
2019 (24)
2016 (24)
2009 (21)
2024 (20)
2021 (19)
2022 (16)
2018 (16)
2007 (9)
2020 (9)
2006 (8)
2005 (6)
2004 (1)

UNIPROT ID/AC

P08047 (1)
Q99650 (1)
Q6PID9 (1)
P35625 (1)
O14522 (1)
Q9Y5Y6 (1)
P60510 (1)
O43187 (1)
Q9BY84 (1)
O75173 (1)
P13725 (1)
P01583 (1)
P45452 (1)
P03956 (1)
P02458 (1)
P01033 (1)
P08254 (1)
Q15759 (1)
Q9Y4K3 (1)
P14778 (1)
P05412 (1)
P01100 (1)
O14543 (1)
P40763 (1)
P28562 (1)
P45983 (1)
P23458 (1)

ENSEMBL ID

ENSG00000100234 (1)
ENSG00000102265 (1)
ENSG00000184557 (1)
ENSG00000137745 (1)
ENSG00000196611 (1)
ENSG00000177606 (1)
ENSG00000170345 (1)
ENSG00000158859 (1)
ENSG00000149968 (1)

CHEBI ID

CHEBI:26271 (3)
CHEBI:16312 (2)
CHEBI:19144 (2)
CHEBI:28125 (2)
CHEBI:30817 (2)
CHEBI:28116 (2)
CHEBI:17169 (2)
CHEBI:17639 (2)
CHEBI:81308 (2)
CHEBI:27915 (2)
CHEBI:37998 (2)
CHEBI:28123 (2)
CHEBI:16870 (2)
CHEBI:25017 (2)
CHEBI:28631 (2)
CHEBI:30746 (2)
CHEBI:30745 (2)
CHEBI:18086 (2)
CHEBI:16235 (2)
CHEBI:36274 (2)
CHEBI:28728 (2)
CHEBI:17847 (2)
CHEBI:132244 (2)
CHEBI:28484 (2)
CHEBI:16919 (2)
CHEBI:15354 (2)
CHEBI:17351 (2)
CHEBI:17368 (2)
CHEBI:17687 (2)
CHEBI:16991 (1)

Metabolite Name

Choline (8)
Adenosine (8)
Creatine (8)
Guanine (7)
Palmitic acid (7)
Adenine (7)
Myristic acid (7)
Inosine (7)
Hypoxanthine (7)
Propionylcarnitine (6)
Lumichrome (6)
Succinic acid (6)
Deoxycholic acid (6)
Malic acid (6)
Proline (6)
Oleic acid (6)
Cytidine (6)
Guanosine (6)
L-Tyrosine (6)
Pyruvic acid (5)
Pentadecanoic acid (5)
Uracil (5)
Citrulline (5)
Pantothenic acid (5)
Indole (5)
DL-Arginine (5)
Arachidonic acid (5)
3-Hydroxybutyric acid (5)
Oleamide (5)
Sarcosine (5)

First Public Date

2014 (47)
2025 (27)
2026 (23)
2024 (16)
2023 (14)
2021 (14)
2017 (8)
2019 (6)
2018 (6)
2020 (5)
2015 (5)
2022 (4)
2016 (3)
2013 (1)

Modelling Approach

Ordinary differential equation model (4)
Boolean model (1)

Study status

Completed (3)

Lab affiliation

University of Vienna, Faculty of Chemistry, Department of Analytical Chemistry (5)
Proteomics group, Ri.MED Foundation, Palermo, Italy (2)
Biotech Research and Innovation Centre (BRIC), Faculty of Health and Medical Sciences, University of Copenhagen (1)
Bone and Cartilage Research Unit, Arthropôle Liège, University of Liège, Liège, Belgium (1)
Butantan Institute (1)
CENTD, Instituto Butantan (1)
Centre Algatech, Institute of Microbiology, Academy of Sciences of the Czech Republic, 6 Novohradská 237, Třeboň, 379 81, Czech Republic (1)
Centre for Blood Research, Department of Oral Biological and Medical Sciences, University of British Columbia, Vancouver, BC, Canada (1)
Centre for Blood Research, Department of Oral Biological and Medical Sciences, University of British Columbia, Vancouver, BC, Canada. (1)
College of Pharmaceutical Sciences Soochow University Yunxuan Building 1328 199 Ren'ai Road, Suzhou, Jiangsu 215123, China (1)
D.Sc., associate professor Head of Laboratory of Genetic Engineering Research Institute of Physical-Chemical Medicine (1)
Department of Biochemistry, Federal University of São Paulo, Brazil. (1)
Department of Biochemistry, University of Turku, Turku, Finland (1)
Department of Biochemistry/Venom, Antivenom and Natural Toxins Research Centre, Ahmadu Bello University, Zaria (1)
Department of Biology, Faculty of Science, Mahidol University, 272 Rama VI Road, Ratchathewi, Bangkok 10400, Thailand. (1)
Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel (1)
Department of Musculoskeletal and Ageing Science Institute of Life Course and Medical Sciences University of Liverpool, UK (1)
Department of Ophthalmology, Shanghai General Hospital; Shanghai Key Laboratory of Ocular Fundus Disease; Shanghai Engineering Center for Visual Science and Photomedicine, No. 100 Haining Road, Shanghai 200080, China. (1)
Department of Physiology & Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada. McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada. (1)
Department of Proteomics and Signal Transduction, Max-Planck Institute of Biochemistry, Martinsried, Germany (1)
Department of Urology, SUNY Upstate Medical University Syracuse, NY 13210, USA (1)
Department of biochemistry, UNIFESP, Brazil. (1)
Division of Oncology, Rambam Health Care Campus & Rappaport Faculty of Medicine, Technion, Haifa, Israel (1)
Hotchkiss Brain Institute and Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada Departments of Biochemistry and Molecular Biology, and Physiology and Pharmacology, and McCaig Institute for Bone and Joint Health, University of Calgary, Calgary, Canada (1)
Hubei University of Technology (1)
Infectious Diseases and Immunity in Global Health Program, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada (1)
Institute of Microbiology, The Czech Academy of Sciences, Třeboň, Czech Republic (1)
Institute of Molecular Health Sciences, Department of Biology, ETH Zurich (1)
King's British Heart Foundation Centre, King's College London, London, UK (1)
Laboratory of Molecular Bases of Aging Nencki Institute of Experimental Biology (1)

Keyword

Matrilysin (1)
MMP-7 (1)
Lymph nodes (1)
Adenoma (1)
Adenocarcinoma of the colon (1)
Recurrent colon cancer (1)
Stage IV colon cancer (1)
Recurrent rectal cancer (1)
Stage IV rectal cancer (1)
Liver metastases (1)
Adenocarcinoma of the rectum (1)

IsPrivate

False (6)

Modification

N6-dimethyl-L-lysine (2)
4-tetrahydrothiazine-3-carboxylic acid (1)
4x(2)H labeled dimethylated L-lysine (1)

Study type

Transcription profiling by array (215)
RNA-seq of coding RNA (13)
Unknown experiment type (5)
Animal - One-color microarray (3)
Methylation profiling by array (2)
Observational (2)
Transcription profiling by SAGE (1)
ChIP-chip by tiling array (1)
Animal - High-throughput sequencing (1)
Transcription profiling by RT-PCR (1)
ATAC-seq (1)
RNA-seq of non coding RNA (1)
Interventional (1)

Release Date

2022 (327)
2021 (327)
2020 (292)
2023 (285)
2019 (253)
2018 (242)
2025 (228)
2017 (220)
2024 (191)
2016 (180)
2015 (180)
2014 (168)
2012 (143)
2013 (136)
2011 (114)
2010 (112)
2009 (90)
2008 (56)
2026 (39)
2007 (38)
2006 (23)
2005 (19)
2004 (6)
2001 (5)
2003 (4)
1999 (4)
1997 (4)
2002 (3)
2000 (3)
1998 (2)

Location

Iran (1)
Italy (1)

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Upregulation of Expression of Matrix Metalloproteinases in Alveolar Macrophages of HIV1+ Smokers with Early Emphysema

HIV1+ smokers develop emphysema at an earlier age and with a higher incidence than HIV1- smokers. Based on the knowledge that human alveolar macrophages (AM) are capable of producing proteases that degrade extracellular matrix components, we hypothesized that upregulation of AM matrix metalloprotein...

ORGANISM(S): Homo sapiens

2016-03-24 | E-GEOD-10038 | biostudies-arrayexpress

dCas9-mediated transcriptional activation of tissue inhibitor of metalloproteinases.

Not available

S-EPMC5624544 | biostudies-literature

Matrix metalloproteinases, a disintegrin and metalloproteinases, and a disintegrin and metalloproteinases with thrombospondin motifs in non-neoplastic diseases.

Not available

S-EPMC3745773 | biostudies-literature

The gelatinases, matrix metalloproteinases 2 and 9, play individual roles in skeleton development

PRJNA928102 | ENA

Combined Radiochemotherapy: Metalloproteinases Revisited.

Not available