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TranscriptomicsAn MLL/COMPASS subunit functions in the C. elegans dosage compensation complex to target X chromosomes for transcriptional regulation of gene expression
This SuperSeries is composed of the following subset Series: GSE25831: Fed L1 larvae total RNA levels by microarray GSE25833: Examination of DPY-30, DPY-27, SDC-3, DPY-26, MIX-1, SMC-4, ASH-2, RNA Polymerase II binding in wild type embryos, DCC mutant embryos, and wild type fed L1 larvae GSE25877: C...
ORGANISM(S): Caenorhabditis elegans 
2011-03-01 | E-GEOD-25834 | biostudies-arrayexpress
TranscriptomicsA condensin-like dosage compensation complex acts at a distance to control expression throughout the genome
This SuperSeries is composed of the following subset Series: GSE14649: DCC binding and function (Expression Analysis) GSE14650: DCC binding and function (ChIP-chip: SDC-3, MIX-1, DPY-27, Mock) GSE14651: DCC binding and function (ChIP-chip: DPY-27) GSE14652: DCC binding and function (ChIP-chip: SDC-2...
ORGANISM(S): Caenorhabditis elegans 
2010-05-22 | E-GEOD-14640 | biostudies-arrayexpress
TranscriptomicsFed L1 larvae total RNA levels by microarray
Here we exploit the essential process of XM-bM-^@M-^Pchromosome dosage compensation to elucidate basic mechanisms that control the assembly, genomeM-bM-^@M-^Pwide binding, and function of gene regulatory complexes that act over large chromosomal territories. We demonstrate that a subunit of C. ele...
ORGANISM(S): Caenorhabditis elegans 
2011-03-01 | E-GEOD-25831 | biostudies-arrayexpress
TranscriptomicsExamination of DPY-30, DPY-27, SDC-3, DPY-26, MIX-1, SMC-4, ASH-2, RNA Polymerase II binding in wild type and DCC mutant embryos
Here we exploit the essential process of X-chromosome dosage compensation to elucidate basic mechanisms that control the assembly, genome-wide binding, and function of gene regulatory complexes that act over large chromosomal territories. We demonstrate that a subunit of C. elegans MLL/COMPASS, a g...
ORGANISM(S): Caenorhabditis elegans 
2011-03-01 | E-GEOD-25833 | biostudies-arrayexpress
TranscriptomicsDevelopment of GRO-cap (GRO-seq followed by 5'-cap enrichment) to map transcription start sites in C. elegans
Dosage Compensation is required to correct for uneven gene dose between the sexes. We utilized global run-on sequencing (GRO-seq) to examine how Caenorhabditis elegans dosage compensation reduces transcription of X-linked genes. To facilitate these experiments, we required accurate 5M-bM-^@M-^Y-ends...
ORGANISM(S): Caenorhabditis elegans 
2013-06-18 | E-GEOD-43085 | biostudies-arrayexpress
TranscriptomicsComparison of DPY-27 binding in embryos and fed L1 larvae
Here we exploit the essential process of X-chromosome dosage compensation to elucidate basic mechanisms that control the assembly, genome-wide binding, and function of gene regulatory complexes that act over large chromosomal territories. We demonstrate that a subunit of C. elegans MLL/COMPASS, a g...
ORGANISM(S): Caenorhabditis elegans 
2011-03-01 | E-GEOD-25877 | biostudies-arrayexpress
TranscriptomicsUsing GRO-seq experiments to determine the mechanism of C. elegans dosage compensation's control of transcription
Dosage Compensation is required to correct for uneven gene dose between the sexes. We utilized global run-on sequencing (GRO-seq) to examine how Caenorhabditis elegans dosage compensation reduces transcription of X-linked genes. To facilitate these experiments, we required accurate 5M-bM-^@M-^Y-ends...
ORGANISM(S): Caenorhabditis elegans 
2013-06-18 | E-GEOD-43084 | biostudies-arrayexpress
ProteomicsQuantitative proteome analysis of hepatocellular carcinoma tissue
Hepatocellular carcinoma (HCC) is one of the most aggressive tumors and the treatment outcome of this disease is improved when the cancer is diagnosed at early stages. This requires biomarkers allowing for an accurate and early tumor diagnosis. To identify potential markers for such applications we ...
ORGANISM(S): Homo sapiens (Human) 
2016-04-13 | PXD002171 | Pride
Human Srm Tissue Label-free proteomics Hepatocellular carcinoma Bimarkers Mrm Multiple reaction monitoring Early diagnosis biomarker Versican. Targeted proteomics Selected reaction monitoring 
GenomicsBinding of the C. elegans dosage compensation complex protein DPY-27
Dosage Compensation is required to correct for uneven gene dose between the sexes. We utilized global run-on sequencing (GRO-seq) to examine how Caenorhabditis elegans dosage compensation reduces transcription of X-linked genes. To facilitate these experiments, we required accurate 5M-bM-^@M-^Y-ends...
ORGANISM(S): Caenorhabditis elegans 
2013-06-18 | E-GEOD-43086 | biostudies-arrayexpress
TranscriptomicsC. elegans mixed stage embryo total RNA levels by microarray: L4440 RNAi, smo-1 RNAi and sdc-2 (y93)+RNAi
The essential process of dosage compensation equalizes X-chromosome gene expression between C. elegans XO males and XX hermaphrodites through a dosage compensation complex (DCC) that resembles condensin. The DCC binds to both X chromosomes of hermaphrodites to repress transcription by half. Here we ...
ORGANISM(S): Caenorhabditis elegans 
2013-08-31 | E-GEOD-48347 | biostudies-arrayexpress
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