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MetabolomicsFatty acid transport protein 4 is required for incorporation of saturated ultralong-chain fatty acids into epidermal ceramides and monoacylglycerols
Fatty acid transport protein 4 (FATP4) is an acyl-CoA synthetase that is required for normal permeability barrier in mammalian skin. FATP4 (SLC27A4) mutations cause ichthyosis prematurity syndrome, a nonlethal disorder. In contrast, Fatp4-/- mice die neonatally from a defective barrier. H...
2021-07-15 | MTBLS1138 | MetaboLights
UnknownRandomized Trial of Lenalidomide Alone Versus Lenalidomide Plus Rituximab in Patients With Recurrent Follicular Lymphoma: CALGB 50401 (Alliance).
Not available
S-EPMC4622102 | biostudies-literature
TranscriptomicsTranscription profiling of rat mast cells from diabetic prone and diabetic resistant strains
Abstract; Human type 1 diabetes mellitus (T1DM) arises through autoimmune destruction of pancreatic β cells and is modeled in many respects by the lymphopenic and spontaneously diabetic BioBreeding (BB) DRlyp/lyp rat. Previously, pre-onset expression profiling of whole DRlyp/lyp pancreatic lymph...
ORGANISM(S): Rattus norvegicus 
2008-06-13 | E-GEOD-4990 | biostudies-arrayexpress
UnknownMapping interindividual dynamics of innate immune response at single-cell resolution.
Not available
S-EPMC10260404 | biostudies-literature
UnknownTIMEPOINT, a phase 1 study combining MTL-CEBPA with pembrolizumab, supports the immunomodulatory effect of MTL-CEBPA in solid tumors.
Not available
S-EPMC12047497 | biostudies-literature
ProteomicsTIMEPOINT, a phase 1 study of MTL-CEBPA in combination with pembrolizumab, supports the immunomodulatory effect of MTL-CEBPA in solid tumours.
Many cancer patients don’t benefit from currently-approved immune checkpoint inhibitors (ICI), suggesting that additional immunomodulation of the immunosuppressive tumour microenvironment (TME) is required. MTL-CEBPA specifically upregulates expression of master myeloid transcription factor, CEBPA, ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD060726 | Pride
Human Cancer Plasma proteome Immunomodulatory 
UnknownMonogenic early-onset lymphoproliferation and autoimmunity: Natural history of STAT3 gain-of-function syndrome.
Not available
S-EPMC10081938 | biostudies-literature
UnknownAutoantibodies against type I IFNs in patients with critical influenza pneumonia.
Not available
S-EPMC9485705 | biostudies-literature
ProteomicsThe Global Phosphorylation Landscape of SARS-CoV-2 Infection
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the coronavirus disease 2019 (COVID-19) pandemic, has infected over 3 million people worldwide and caused over 200,000 deaths since it emerged in late 2019. There is an urgent need to develop therapies that can limi...
ORGANISM(S): Chlorocebus Aethiops (ncbitaxon:9534) 
2020-07-15 | MSV000085759 | MassIVE
UnknownRecessive inborn errors of type I IFN immunity in children with COVID-19 pneumonia.
Not available
S-EPMC9206114 | biostudies-literature
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