Transcription profiling of rat mast cells from diabetic prone and diabetic resistant strains

ABSTRACT: Abstract; Human type 1 diabetes mellitus (T1DM) arises through autoimmune destruction of pancreatic β cells and is modeled in many respects by the lymphopenic and spontaneously diabetic BioBreeding (BB) DRlyp/lyp rat. Previously, pre-onset expression profiling of whole DRlyp/lyp pancreatic lymph nodes (PLN) revealed innate immune activity, specifically that of mast cells and eosinophils. Furthermore, we observed that pancreatic islets of DRlyp/lyp rats as well as those of diabetes-inducible BB DR+/+ rats potentially recruit innate cells through eotaxin expression. Here we determine that lifelong eotaxin expression begins before 40 days of life and localized specifically to β cells. In this report, we find PLN mast cells more abundant in DRlyp/lyp compared to related BB DR+/+ rats (2.

ORGANISM(S): Rattus norvegicus

SUBMITTER: Lisa Ann Meyer 

PROVIDER: E-GEOD-4990 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress