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ProteomicsPhosphorylation of a nuclear condensate regulates cohesion and mRNA retention
Nuclear speckles are membraneless organelles that associate with active transcription sites and participate in post-transcriptional mRNA processing. During the cell cycle, nuclear speckles dissolve following phosphorylation of their protein components. Here, we identify the PP1 family as the phospha...
ORGANISM(S): Homo sapiens (Human) 
2024-11-28 | PXD055775 | Pride
Nuclear speckles Dyrk3 Phosphatase Kinase 
ProteomicsMutations in disordered regions cause disease by creating dileucine motifs - peptide-protein interaction screen
Many disease-causing missense mutations affect intrinsically disordered regions (IDRs) of proteins. Since these mutations do not affect protein structure, the molecular mechanism of their pathogenicity is enigmatic. Here, we employ a peptide-based proteomic screen to investigate the impact of mutati...
ORGANISM(S): Homo sapiens (Human) 
2018-09-13 | PXD010027 | Pride
Peptide array Ppi Protein-protein interaction Disordered regions 
ProteomicsMutations in disordered regions cause disease by creating dileucine motifs - BioID
Many disease-causing missense mutations affect intrinsically disordered regions (IDRs) of proteins. Since these mutations do not affect protein structure, the molecular mechanism of their pathogenicity is enigmatic. Here, we employ a peptide-based proteomic screen to investigate the impact of mutati...
ORGANISM(S): Homo sapiens (Human) 
2018-09-13 | PXD010061 | Pride
Bioid Proximity labeling 
ProteomicsHuman Calu-3 cell lipidome response to a wild type infectious clone of H7N9 and mutant H7N9 viruses
Lipidomics data from Calu-3 cell culture; Treated with wild-type and mutant H7N9 and mockulum; Time points 0, 3, 7, 12, 18 & 24 h; 5 biological replicates
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2015-11-23 | MSV000079386 | MassIVE
ProteomicsPrimary human airway epithelial cells metabolome response to an icMERS coronavirus
Metabolomics data from cell culture; time points 0, 12, 24, 36 & 48 h
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Middle East Respiratory Syndrome-related Coronavirus (ncbitaxon:1335626) 
2018-01-05 | MSV000081890 | MassIVE
ProteomicsPrimary human airway epithelial cells metabolome response to an icMERS coronavirus
Metabolomics data from cell culture; time points 0, 12, 24, 36 & 48 h
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Middle East Respiratory Syndrome-related Coronavirus (ncbitaxon:1335626) 
2018-01-05 | MSV000081889 | MassIVE
ProteomicsCalu-3 cell lipidome response to a wild type H5N1 and mutants Influenza viruses
Lipidomics data from Calu-3 cell culture; Treated with wild-type and mutant H5N1 and mockulum; Time points 0, 3, 7, 12, 18 & 24 h; 5 biological replicates
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-08-04 | MSV000080023 | MassIVE
ProteomicsCalu-3 metabolome response to an infectious clone of H7N9 Influenza virus and mutant H7N9 viruses
Metabolomics data from Calu-3 cell culture; Treated with wild-type and mutant H7N9 and mockulum; Time points 0, 3, 7, 12, 18 & 24 h; 5 biological replicates
ORGANISM(S): Human Calu-3 Cell Homo Sapiens (ncbitaxon:9606) 
2015-06-11 | MSV000079156 | MassIVE
ProteomicsMouse lung metabolome response to a wild type infectious clone of H7N9 Influenza virus and mutants
Metabolomics data from mouse lung; Treated with wild-type and mutant H7N9 and mockulum; Time points 1, 2, 4 & 7 days; 5 biological replicates
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2015-07-31 | MSV000079206 | MassIVE
ProteomicsHuman Calu-3 cell proteome response to a wild type infectious clone of H5N1 and mutant H5N1 viruses
Lipidomics data from Calu-3 cell culture; Treated with wild-type and mutant H5N1 and mockulum; Time points 0, 3, 7, 12, 18 & 24 h; 5 biological replicates
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2016-01-18 | MSV000079459 | MassIVE
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