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ProteomicsKinase activity of DYRK family members is required for regulating primary cilium length, stability and morphology
The dual-specificity tyrosine-phoshorylation-regulated kinase (DYRK) family are multifunctional enzymes crucial for diverse cellular processes, including signaling through the primary cilium. Their dysregulation has been implicated in various cancers and developmental disorders, highlighting the nee...
ORGANISM(S): Homo sapiens (Human) 
2025-06-10 | PXD064683 | Pride
Dyrk3 Primary cilium Bioid 
ProteomicsDYRK3 protein-protein interactions in human cells
Quantitative affinity purification experiment was performed to identify the protein interactors of DYRK3 kinase in human cells. An additional pull-down experiment was carried out to study the changes of DYRK3 interactors with GSK-626616 kinase inhibitor treatment.
ORGANISM(S): Homo sapiens (Human) 
2018-07-05 | PXD007761 | Pride
Ap-ms Dyrk3 Silac Kinase inhibitor 
ProteomicsLable-free LC-MSMS in HeLa on DYRK3 and Sec16A, Human cervical cancer cells
In order to identify sites of the SEC16A specifically phosphorylated by the Dual Specificity Kinase DYRK3, mCherry-SEC16A was transiently over expressed in HeLa cells together with GFP-DYRK3 or EGFP-C1 only
ORGANISM(S): Homo sapiens (Human) 
2023-06-23 | PXD041620 | Pride
Hela Lable-free lc-msms Dyrk3 Sec16a 
ProteomicsIdentification of DYRK3 interaction partners by immunoprecipitation-MS and TurboID
Proteins that interact with overexpressed GFP-DYRK3 were pulled down for identification by LC-MS/MS. Interaction strength and likelihood were calculated by comparison to pulldown of GFP alone. Data were compared to Turbo-ID proximity labelling data for DYRK3 in HeLa cells to identify consistently as...
ORGANISM(S): Homo sapiens (Human) 
2023-06-23 | PXD041550 | Pride
Hek293t cells Hela cells Turboid Dyrk3 Phosphorylation Immunoprecipitation Kinase 
UnknownDYRK3 phosphorylates SNAPIN to regulate axonal retrograde transport and neurotransmitter release
Not available
S-EPMC9803678 | biostudies-literature
UnknownDual specificity kinase DYRK3 regulates cell migration by influencing the stability of protrusions.
Not available
S-EPMC10952033 | biostudies-literature
UnknownDual Specificity Kinase DYRK3 Promotes Aggressiveness of Glioblastoma by Altering Mitochondrial Morphology and Function.
Not available
S-EPMC8000785 | biostudies-literature
UnknownPAICS/DYRK3 Multienzyme Interactions as Coregulators of Purinosome Formation and Metabolism on Radioresistance in Oral Squamous Cell Carcinoma.
Not available
S-EPMC10744311 | biostudies-literature
UnknownDYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1.
Not available
S-EPMC2857074 | biostudies-literature
UnknownInvasion of Cryptococcus neoformans into human brain microvascular endothelial cells is mediated through the lipid rafts-endocytic pathway via the dual specificity tyrosine phosphorylation-regulated kinase 3 (DYRK3).
Not available
S-EPMC3186382 | biostudies-literature
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