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MetabolomicsPREDICT: untargeted metabolomic profiling in a Brassica napus (canola) breeding population by GC-MS

Genome-wide association studies (GWAS) identified thousands of genetic loci associated with complex plant traits, including many traits of agronomical importance. However, functional interpretation of GWAS results remains challenging because of large candidate regions due to linkage disequilibriu...

2023-11-20 | MTBLS8056 | MetaboLights
UnknownGraffinity: Visualizing Connectivity in Large Graphs.
Not available
S-EPMC5821473 | biostudies-literature
TranscriptomicsDNA Methylation profiling of human iNBSCs, iPSC-derived NBSCs and adult dermal fibroblasts
We describe a so far uncharacterized, embryonic and self-renewing Neural Plate Border Stem Cell (NBSC) population with the capacity to differentiate into central nervous and neural crest lineages. NBSCs can be obtained by neural transcription factor-mediated reprogramming (BRN2, SOX2, KLF4, and ZIC3...
ORGANISM(S): Homo sapiens 
2018-12-20 | E-MTAB-5808 | biostudies-arrayexpress
TranscriptomicsProspective derivation of a 'Living Organoid Biobank' of colorectal cancer patients
In Rspondin-based three-dimensional cultures, Lgr5 stem cells from multiple organs form ever-expanding epithelial organoids that retain their tissue identity. Here we report the establishment of tumor organoid cultures from 20 consecutive colorectal carcinoma (CRC) patients. For most, organoids were...
ORGANISM(S): Homo sapiens 
2015-05-07 | E-GEOD-65253 | biostudies-arrayexpress
UnknownRod-cone crossover connectome of mammalian bipolar cells.
Not available
S-EPMC5823792 | biostudies-literature
ProteomicsDisease-linked lysine glutarylation impairs function and interactions of mitochondrial proteins and contribute to mitochondrial heterogeneity
Inherited deficiencies of the lysine and tryptophan catabolic pathways, due to mutations in the glutaryl-CoA-dehydrogenase (GCDH) gene, cause glutaric aciduria type 1 (GA1). In mammals two metabolic routes for L-lysine oxidation exist, the mitochondrial saccharopine pathway, which is predominant in ...
ORGANISM(S): Mus musculus (Mouse) 
2018-07-11 | PXD007881 | Pride
Metabolism Molecular biology of disease Protein interaction Glutaryl-coa-dehydrogenase Glutaryl-proteome Proteolysis & proteomics Post-translational modifications Glutamate dehydrogenase 
TranscriptomicsSingle cell RNA-sequencing of induced Neural Plate Border Stem Cells
We describe a so far uncharacterized, embryonic and self-renewing Neural Plate Border Stem Cell (NBSC) population with the capacity to differentiate into central nervous and neural crest lineages. NBSCs can be obtained by neural transcription factor-mediated reprogramming (BRN2, SOX2, KLF4 and ZIC3)...
ORGANISM(S): Homo sapiens 
2018-12-20 | E-MTAB-6911 | biostudies-arrayexpress
TranscriptomicsRNA Expression profiling of human induced Neural Plate Border Stem Cells, Neural Plate Border Stem Cell progeny and biological controls
We describe a so far uncharacterized, embryonic and self-renewing Neural Plate Border Stem Cell (NBSC) population with the capacity to differentiate into central nervous and neural crest lineages. NBSCs can be obtained by neural transcription factor-mediated reprogramming (BRN2, SOX2, KLF4, and ZIC3...
ORGANISM(S): Homo sapiens 
2018-12-20 | E-MTAB-5804 | biostudies-arrayexpress
ProteomicsProteogenomics reveals two distinct biological pilocytic astrocytoma subgroups
Pilocytic astrocytoma (PA) is the most common pediatric brain tumor and driven by aberrant MAPK signaling, typically mediated by BRAF alterations. While five-year overall survival rates exceed 95%, tumor recurrence constitutes a major clinical challenge in incompletely resected tumors despite chemot...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD035773 | Pride
Lc-msms Pilocytic astrocytoma Brain tumour 
ProteomicsEnzymatic dissociation induces transcriptional and proteotype bias in brain cell populations
Different cell isolation techniques exist for transcriptomic and proteotype profiling of brain cells. Here we show that standard enzymatic digestion of brain tissue at 37°C induces profound alterations in the transcriptome and proteotype of specific brain cells, as compared to cold mechanical dissoc...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-08 | PXD015592 | Pride
Brain cell types enzymatic digestion bias isolation 
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