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TranscriptomicsTranscription profiling of human Jurkat T leukemia cells to detect anticancer metabolites discovered by computational metabolomics
CoMet, a fully automated Computational Metabolomics method to predict changes in metabolite levels in cancer cells compared to normal references has been developed and applied to Jurkat T leukemia cells with the goal of testing the following hypothesis: up or down regulation in cancer cells of the e...
ORGANISM(S): Homo sapiens 
2008-10-20 | E-GEOD-9648 | biostudies-arrayexpress
TranscriptomicsExpression data from breast cancer cell line MCF-7 with ectopic expression of the transcription factor Snail
The transcription factor Snail has been proposed to mediate epithelial-to-mesenchymal transition (EMT) and confer mesenchymal invasive phenotype to epithelial cancer cells To analyze the molecular effects of ectopic Snail expression on an epithelial breast cancer cell line, gene expression profiles ...
ORGANISM(S): Homo sapiens 
2014-07-29 | E-GEOD-58252 | biostudies-arrayexpress
MetabolomicsOVCAR-3 spheroid-derived cells display distinct metabolic profiles
Recently, multicellular spheroids were isolated from a well-established epithelial ovarian cancer cell line, OVCAR-3, and were propagated in vitro. These spheroid derived cells displayed numerous hallmarks of cancer stem cells, which are chemo and radioresistant cells thought to be a significant cau...
2015-01-08 | MTBLS152 | MetaboLights
TranscriptomicsIsolation and characterization of stem-like cells from a human ovarian cancer cell line
Increasing evidence supports the existence of a subpopulation of cancer cells capable of self-renewal and differentiation into diverse cell lineages. These cancer stem-like or cancer initiating cells (CICs) also demonstrate resistance to chemo- and radiotherapy and may function as a primary source o...
ORGANISM(S): Homo sapiens 
2011-04-23 | E-GEOD-28799 | biostudies-arrayexpress
TranscriptomicsmiRNAs in ovarian cancer: A systems approach (miRNA data)
MicroRNAs (miRNAs) are short (~22 nucleotides) regulatory RNAs that can modulate gene expression and are aberrantly expressed in many diseases including cancer. We report the results of a systems analysis of miRNA regulation in ovarian cancer. We found that 33 miRNAs are up-regulated and 9 down-regu...
ORGANISM(S): Homo sapiens 
2011-07-28 | E-GEOD-23383 | biostudies-arrayexpress
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