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ProteomicsMGAT1-Mediated Glycosylation Orchestrates Immune Checkpoints and Antitumor Immunity
Despite the widespread application of immunotherapy, treating immune-cold tumors remains a significant challenge in cancer therapy. Using multiomic spatial analyses and experimental validation, we have identified MGAT1, a glycosyltransferase, as a pivotal factor governing tumor immune response. Over...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD055157 | Pride
Mgat1  glycosylation  cd73  tumor immunogenicity  drug design and therapeutics 
Proteomicssurface proteome of WT vs. MGAT1 KO HeLa cells
Using cell-surface biotinylation followed by mass spectrometry (MS), we revealed substantial differences between the surface proteomes of WT and MGAT1 KO HeLa cells. Among the most strongly depleted proteins in MGAT1 KO cells were those involved in cell adhesion and extracellular interactions, membr...
ORGANISM(S): Homo sapiens (Human) 
2026-09-05 | PXD083032 | Pride
Surface proteome Mgat1 
UnknownSuppression of cancer progression by MGAT1 shRNA knockdown.
Not available
S-EPMC3434202 | biostudies-literature
UnknownMGAT1 and Complex N-Glycans Regulate ERK Signaling During Spermatogenesis.
Not available
S-EPMC5792458 | biostudies-literature
GenomicsGenetic and biochemical screens identify MGAT1 as a druggable glycosyltransferase target in STK11-mutant lung cancer
Genetic and biochemical screens identify MGAT1 as a druggable glycosyltransferase target in STK11-mutant lung cancer
PRJNA1519743 | ENA
UnknownIdentification of a gene encoding MGAT1, a monoacylglycerol acyltransferase.
Not available
S-EPMC124292 | biostudies-literature
TranscriptomicsComparison of microarray expression data from 23 day mouse germ cells from control and Mgat1 conditional knockout mice
Loss of Mgat1 in spermatogonia was investigated in germ cells from 23 day males. Gene expression changes induced by deletion of Mgat1 were determined using the Affymetrix GeneChip Mouse Gene 2.0 ST Array. We include the expression data obtained from three replicate aliquots of pooled testis total RN...
ORGANISM(S): Mus musculus 
2018-02-13 | GSE99034 | GEO
TranscriptomicsComparison of microarray expression data from 22 day mouse germ cells from control and Mgat1 conditional knockout mice
Mechanistic insights into MGAT1 loss during spermatogenesis were investigated in germ cells from 22 day males. Gene expression changes induced by deletion of Mgat 1in spermatogonia were determined using the Affymetrix GeneChip Whole Transcript Plus Reagent Kit. We include the expression data obtaine...
ORGANISM(S): Mus musculus 
2018-02-13 | GSE99033 | GEO
UnknownTransgenic Rescue of Spermatogenesis in Males With Mgat1 Deleted in Germ Cells.
Not available
S-EPMC7142241 | biostudies-literature
OtherGenetic and biochemical screens identify MGAT1 as a druggable glycosyltransferase target in STK11-mutant lung cancer
Checkpoint inhibitors are standard-of-care therapies for non-small cell lung cancer (NSCLC), but their efficacy is limited in tumors with STK11 mutations, highlighting the need for new therapeutic strategies. Here, we performed complementary in vivo and in vitro CRISPR-Cas9 functional genomic screen...
ORGANISM(S): Homo sapiens Mus musculus 
2026-10-02 | GSE345281 | GEO
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