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UnknownConnecting MHC-I-binding motifs with HLA alleles via deep learning.
Not available
S-EPMC8523706 | biostudies-literature
ProteomicsThe length distribution of MHC-I binding peptides
The current study provides an opportunity to identify specific MHC I motifs in vitro. The combination of random peptide library, LC-MS/MS and De Novo Sequencing can be an important complement to the identification of MHC I motif. Insight into the length distribution of MHC-I binding peptides helps u...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2022-02-25 | PXD020818 | Pride
Swine mhc class i，random peptide library，lc-ms/ms，de novo sequencing 
ProteomicsMachine learning predictions of MHC-II specificities reveal alternative binding mode of class II epitopes
CD4+ T cells orchestrate the adaptive immune response against pathogens and cancer by recognizing epitopes presented on MHC-II molecules. The high polymorphism of MHC-II genes represents an important hurdle towards accurate predictions of CD4+ T-cell epitopes in different individuals and different s...
ORGANISM(S): Homo sapiens (Human) 
2023-04-07 | PXD034773 | Pride
Hla-ii binding motifs Machine learning predictions Hla-ii peptides 
ProteomicsNNAlign_MA; MHC peptidome deconvolution for accurate MHC binding motif characterization and improved T cell epitope predictions
Current mass spectrometry technologies allow for identification of MHC-associated peptide ligands. Studies have proven these data to be a rich source of information for learning the rules of MHC-mediated antigen presentation. Such immunopeptidomes are usually poly-specific, containing multiple seque...
ORGANISM(S): Bos taurus (Bovine) 
2019-10-07 | PXD015240 | Pride
Immunopeptidomics Bola ligandome 
ProteomicsPeptidomes of MHC Class I Allotypes Illustrate the Peptide binding Plasticity Leading by Micropolymorphism
The current study provides an opportunity to identify specific MHC I motifs in vitro.The combination of random peptide library,LC-MS/MS and De Novo Sequencing can be an important complement to the identification of MHC I motif.
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2021-09-09 | PXD019523 | Pride
Mhc class i，random peptide library，lc-ms/ms，de novo sequencing 
ProteomicsDigging deeper into the HLA peptidome – Characterization of the post-translationally modified peptides
Peptides displayed by MHC molecules on a cell’s surface, referred to as its immunopeptidome, play an important role in the adaptive the immune response. Antigen processing for MHC class I presentation is a ubiquitous pathway present in all nucleated cells which generate and present peptides of both ...
ORGANISM(S): Homo sapiens (Human) 
2021-06-07 | PXD024562 | Pride
Spliced peptides Immunopeptidome Post-translational modifications Mhc class i Mhc binding motifs 
UnknownPeptide-binding motifs of two common equine class I MHC molecules in Thoroughbred horses.
Not available
S-EPMC5555743 | biostudies-literature
UnknownThe MHC Motif Atlas: a database of MHC binding specificities and ligands.
Not available
S-EPMC9825574 | biostudies-literature
UnknownGAMMA: gap-aware motif mining under incomplete labeling with applications to MHC motifs.
Not available
S-EPMC12866627 | biostudies-literature
UnknownQuantitative peptide binding motifs for 19 human and mouse MHC class I molecules derived using positional scanning combinatorial peptide libraries.
Not available
S-EPMC2248166 | biostudies-literature
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