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MetabolomicsRegulatory T cells promote endurance exercise adaptation by shielding muscle mitochondria from damage

Exercise enhances physical performance and reduces the risk of many disorders such as cardiovascular disease, type 2 diabetes, dementia and cancer. Exercise characteristically incites an inflammatory response, notably in skeletal muscles. While some effector mechanisms have been identified, regul...

2023-10-10 | MTBLS8391 | MetaboLights
TranscriptomicsDifferentially activated CD8 T cells in liver and gut
NaM-CM-/ve, liver- and gut-activated CD8 OT-I T cells show differential migration behaviour. To analyze which genes could be responsible for different migration patterns, naM-CM-/ve, liver-activated and gut-activated CD8 T cells were isolated and compared for their gene expression profile. Gene expr...
ORGANISM(S): Mus musculus 
2014-02-25 | E-GEOD-39449 | biostudies-arrayexpress
TranscriptomicsInfluence of isolation procedure and storage condition on the ex vivo gene expression pattern in peripheral human effector/memory T helper lymphocytes
Gene expression profiling of cells isolated ex vivo is a unique tool to assess gene expression in vivo. Exemplified for CD4+CD45RO+ effector/memory T helper (T E/M) lymphocytes of human peripheral blood, we have analyzed different isolation procedures and storage conditions for the introduction of b...
ORGANISM(S): Homo sapiens 
2014-03-24 | E-GEOD-54247 | biostudies-arrayexpress
TranscriptomicsHuman lung minimally invasive adenocarcinoma (MIA): lepidic growth (LG) cancer cell pool vs. micro-invasion (MI) cancer cell pool
Transcriptional profiling of human lung minimally invasive adenocarcinoma cells comparing control lepidic growth (LG) cell pool with micro-invasion (MI) cell pool. Two-condition experiment, LG vs. MI cell pools. Biological replicates: 1 control LG cancer cell, 1 MI cancer cell in an individual MIA t...
ORGANISM(S): Homo sapiens 
2012-01-02 | E-GEOD-30663 | biostudies-arrayexpress
TranscriptomicsGene expression of resting memory, resting naive and in vitro activated memory CD8+CD127+ T cells from spleen and bone marrow (BM)
To understand differences between resting and activated memory CD8+ T cells, we compared the global gene expression of ex vivo isolated naive and spleen and BM memory cells to in vitro activated spleen and BM memory cells. Single cell suspension from the spleen and bones of aged C57BL/6 mice were pr...
ORGANISM(S): Mus musculus 
2015-02-05 | E-GEOD-62691 | biostudies-arrayexpress
TranscriptomicsHuman memory T cells of the bone marrow are resting and maintain long-lasting memory
To compare human memory CD4+ T cell subsets in peripheral blood (PB) and bone marrow (BM) of healthy individuals at transcriptional level, we analyzed the global gene expression of ex vivo PB CD69- as well as BM CD69- and CD69+ memory CD4+ T cells from 4 paired PB and BM samples. The gene expression...
ORGANISM(S): Homo sapiens 
2014-06-17 | E-GEOD-50677 | biostudies-arrayexpress
GenomicsCore transcriptional regulatory circuit controlled by the tal1 complex in human t-cell acute lymphoblastic leukemia (Subseries)
The oncogenic transcription factor TAL1/SCL is aberrantly overexpressed in over 40% of cases of T-cell acute lymphoblastic leukemia (T-ALL), emphasizing the importance of the TAL1-regulated transcriptional program in the molecular pathogenesis of T-ALL. Here we identify the core transcriptional regu...
ORGANISM(S): Homo sapiens 
2012-03-14 | E-GEOD-33850 | biostudies-arrayexpress
TranscriptomicsDiscovery of novel recurrent mutations and rearrangements in early T-cell precursor acute lymphoblastic leukemia by whole genome sequencing
Early T-cell precursor acute lymphoblastic leukaemia (ETP ALL) is an aggressive malignancy of unknown genetic basis. We performed whole genome sequencing of tumour and normal DNA from 12 children with ETP ALL and assessed the frequency of somatic alterations in 52 ETP and 42 non-ETP T-ALL samples by...
ORGANISM(S): Homo sapiens 
2011-11-23 | E-GEOD-28703 | biostudies-arrayexpress
GenomicsMITF ChIP-seq in primary melanocyte and melanoma as a function of oncogenic BRAF
Thousands of enhancers are characterized in the human genome, yet few have been shown important in cancer. Inhibiting oncokinases, such as EGFR, ALK, HER2, and BRAF, is a mainstay of current cancer therapy but is hindered by innate drug resistance mediated by upregulation of the HGF receptor, MET. T...
ORGANISM(S): Homo sapiens 
2014-01-14 | E-GEOD-50681 | biostudies-arrayexpress
TranscriptomicsT cell dependent immune responses: B cell activation and differentiation Group1 Fo, Group2 GC1, Group3 GC2
Upon immunization with a T cell dependent antigen naive follicular B cells (Fo) are activated and a germinal center reaction is induced. Within the next 2 weeks large germinal centers develop where the process of affinity maturation takes place. To analyze the gene expression profile of resting and ...
ORGANISM(S): Mus musculus 
2011-03-29 | E-GEOD-28237 | biostudies-arrayexpress
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