Sort   by:  
 Page size 
MetabolomicsGlobal Metabolomic Profiling of Mice Brains following Experimental Infection with the Cyst-Forming Toxoplasma gondii
The interplay between the Apicomplexan parasite Toxoplasma gondii and its host has been largely studied. However, molecular changes at the metabolic level in the host central nervous system and pathogenesis-associated metabolites during brain infection are largely unexplored. We used a global metabo...
2017-01-27 | MTBLS217 | MetaboLights
MetabolomicsHuman Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice
Autism spectrum disorder (ASD) manifests as alterations in complex human behaviors including social communication and stereotypies. In addition to genetic risks, the gut microbiome differs between typically-developing (TD) and ASD individuals, though it remains unclear whether the microbiome contrib...
2019-07-04 | MTBLS726 | MetaboLights
TranscriptomicsTranscription profiling of mouse brains following nicotine-induced seizures
Nicotine, acting through the neuronal nicotinic acetylcholine receptors (nAChR), can induce seizures in mice. We aimed to study brain transcriptional response to seizure and to identify genes whose expression is altered after nicotine-induced seizures. Whole brains of untreated mice were compared to...
ORGANISM(S): Mus musculus 
2008-04-09 | E-GEOD-6614 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of brains from wild type and beta4 nicotinic acetylcholine receptor (nAChR) subunit deficient mice to identify genes that might be related to beta4-containing nAChRs activity
Studies using mice with beta4 nicotinic acetylcholine receptor (nAChR) subunit deficiency (beta4-/- mice) helped reveal the roles of this subunit in bradycardiac response to vagal stimulation, nicotine-induced seizure activity and anxiety. In order to identify genes that might be related to beta4-co...
ORGANISM(S): Mus musculus 
2007-11-27 | E-GEOD-5320 | biostudies-arrayexpress
MetabolomicsNeuronal Hyperactivity due to Loss of Inhibitory Tone in APOE4 Mice Lacking Alzheimer’s Disease-like Pathology
Metabolite profiling was performed on metabolites extracted from the entorhinal cortex and primary visual cortex of 14-15 month old APOE3/3, APOE3/4 and APOE4/4 mice. Metabolites were run on a TOF Mass Spectrometer using an ANP column. Initial analysis was done in an untargeted manner, and processin...
2017-09-05 | MTBLS530 | MetaboLights
TranscriptomicsGlobal gene expression in P0 Gtf2ird1-/- mouse brains
A compairson of gene expression in the brains of P0 Gtf2ird1-/- and wildtype mice using the GeneChip Mouse Genome 430 2.0 Array (Affymetrix)
ORGANISM(S): Mus musculus 
2011-12-31 | E-MTAB-622 | biostudies-arrayexpress
ProteomicsPhospho-proteome of obese mice brains
This study aims to investigate changes in phospho-proteomic levels of mice brain. The focus of the study is the phospho-proteome because phoshorylation is one of the key post-translational modification, which regulates many biological processes. In particular we wanted to inspect the effects of two ...
ORGANISM(S): Mus musculus (Mouse) 
2018-06-10 | PXD005815 | Pride
Obesity Diet Cns development Mice brains Phospho-proteome 
TranscriptomicsExpression data from post mortem Alzheimer's disease brains
To identify molecular pathological alterations in AD brains, we performed interspecies comparative microarray analyses using RNAs prepared from postmortem human brain tissues donated for the Hisayama study and hippocampal RNAs from the triple-transgenic mouse model of AD (3xTg-AD) Three-way ANOVA of...
ORGANISM(S): Homo sapiens 
2013-04-17 | E-GEOD-36980 | biostudies-arrayexpress
TranscriptomicsExpression data of Brain CD45+ cells from WT and STI knockout mice after WNV infection
West Nile virus (WNV) is the most important cause of endemic encephalitis in the USA. Strikingly, only a small percentage of patients develop clinical disease and of these patients, approximately 1 out of 150 patients develops encephalitis. The basis for this great variability in disease outcome is ...
ORGANISM(S): Mus musculus 
2016-03-22 | E-GEOD-79417 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse scrapie ME7-infected and mock-infected brains at two important preclinical time points and at terminal stages
The experiment describes the dynamic transcriptional alterations in brains of ME7- infected, and age-matched, mock-inoculated mice immediatly before inoculation, at two important preclinical time points and at terminal stages.
ORGANISM(S): Mus musculus 
2007-05-04 | E-MEXP-1005 | biostudies-arrayexpress
Sort   by:  
 Page size