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Phospho-proteome of obese mice brains

ABSTRACT: This study aims to investigate changes in phospho-proteomic levels of mice brain. The focus of the study is the phospho-proteome because phoshorylation is one of the key post-translational modification, which regulates many biological processes. In particular we wanted to inspect the effects of two different kinds of diet (hyperglycemic diet and high-fat diet) compaired with a conventional chow diet. We have found interesting changes in the phosphorylation state of several proteins involved in nervous system development as well as vesicle trafficking and cytoskeleton remodelling.We hope that our study can contribute to elucidating the impact that obesity could have on the brain phospho-proteome.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain

SUBMITTER: Valentina Siino

LAB HEAD: Peter James

PROVIDER: PXD005815 | Pride | 2018-06-10

REPOSITORIES: Pride

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			Action	DRS
	151202_VS_C1_B1_A.mgf	Mgf
	151202_VS_C1_B1_A.mzML.gz	Mzml
	151202_VS_C1_B1_B.mgf	Mgf
	151202_VS_C1_B1_B.mzML.gz	Mzml
	151202_VS_C1_B1_C.mgf	Mgf

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Publications

Impact of diet-induced obesity on the mouse brain phosphoproteome.

Siino Valentina V Amato Antonella A Di Salvo Francesca F Caldara Gaetano Felice GF Filogamo Marcello M James Peter P Vasto Sonya S

The Journal of nutritional biochemistry 20180501

Obesity is closely associated to several diseases such as type 2 diabetes, cardiovascular disease, hepatic steatosis, airway disease, neurodegeneration, biliary diseases and certain cancers. It is, therefore, of importance to assess the role of nutrition in disease prevention as well as its effect in the course of such pathologies. In the present study, we addressed the impact of the exposure to different obesogenic diets in the mice brains phosphoproteome. To analyze if the obesity could be abl ...[more]

PMID: 29886190

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