Sort   by:  
 Page size 
MetabolomicsChronic exposure to tire rubber-derived contaminant 6PPD-quinone impairs sperm quality and induces the damage of reproductive capacity in male mice

The study investigates the effects of 6PPDQ on male fertility in adult mice. The findings of this study are essential as the effects of low-dose environmental factors of 6PPDQ on adult male infertility are unclear, with the increasing in male infertility. The results suggest that 6PPDQ adversely ...

2025-07-14 | MTBLS9432 | MetaboLights
MetabolomicsTEX44 CPT1B Axis Regulates Mitochondrial Sheath Assembly and Fatty Acid Oxidation in Sperm
Mitochondrial fatty acid β-oxidation (FAO) is essential for energy production and cellular homeostasis, yet its specific role in sperm function has remained unclear. Through whole-exome sequencing of 673 patients with asthenozoospermia, we identified biallelic TEX44 variants in six individuals, all ...
2025-07-14 | MTBLS12397 | MetaboLights
MetabolomicsTEX44 CPT1B Axis Regulates Mitochondrial Sheath Assembly and Fatty Acid Oxidation in Sperm

Mitochondrial fatty acid β-oxidation (FAO) is essential for energy production and cellular homeostasis, yet its specific role in sperm function has remained unclear. Through whole-exome sequencing of 673800 patients with asthenozoospermia, we identified biallelic TEX44 variants in six individuals...

2025-07-14 | MTBLS12402 | MetaboLights
ProteomicsMouse Sperm TMT MCP
Mouse Sperm Proteomic Profiling - University of Newcastle - Dr. Matt Dun
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2018-06-24 | MSV000082497 | MassIVE
TranscriptomicsThe Partitioning of RNAs in sperm
A diverse pool of RNAs remain encapsulated within the transcriptionally and translationally silent spermatozoon. These transcripts persist within the male gamete despite the dramatic reduction in cellular volume achieved through expulsion of the cytoplasm and quite possibly the nucleoplasm. The prec...
ORGANISM(S): Mus musculus 
2015-07-08 | E-GEOD-62874 | biostudies-arrayexpress
TranscriptomicsBiogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals (single embryo)
Parental dietary conditions can influence the metabolic traits of offspring. In mice, paternal consumption of low protein diet alters cholesterol and lipid metabolism of progeny. Here, we examine RNA species expressed in male reproductive tissues of mice. Protein restriction leads to altered levels ...
ORGANISM(S): Mus musculus 
2015-12-31 | E-GEOD-75765 | biostudies-arrayexpress
TranscriptomicsA Restricted Role for Sperm-borne MicroRNAs in Mammalian Fertilization
Prototypical micro RNAs (miRNAs) are 21~25-base-pair RNAs that regulate differentiation, carcinogenesis and pluripotency by eliminating mRNAs or blocking their translation, processes collectively termed RNA interference (RNAi). RNAi mediated by miRNAs regulates early development in zebrafish, and mo...
ORGANISM(S): Mus musculus 
2010-06-10 | E-GEOD-4011 | biostudies-arrayexpress
GenomicsHigh-resolution mapping of chromatin packaging in mouse embryonic stem cells and sperm
Mammalian embryonic stem (ES) cells and sperm exhibit unusual chromatin packaging that plays important roles in cellular function. Here, we extend a recently developed technique, based on deep paired-end sequencing of lightly digested chromatin, to assess footprints of nucleosomes and other DNA-bind...
ORGANISM(S): Mus musculus 
2014-07-08 | E-GEOD-58101 | biostudies-arrayexpress
Transcriptomicssmall RNA deep-sequencing of mature sperm, testis and uterus in mice
In order to discover novel small RNAs expressed in mature sperm, we isolated mature sperm from mouse cauda epididymis, comparing with data from adult tesis and uterus. The small RNA fraction (18-40nt) was cloned and sequenced from total RNA of mature sperm, testis and uterus of mice. RNAs extracted ...
ORGANISM(S): Mus musculus 
2013-01-31 | E-GEOD-38702 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse wild type and Taf7l mutant testes
TFIID is a general transcription factor required for transcription of most protein-coding genes by RNA polymerase II. TAF7L is an X-linked germ cell-specific paralogue of TAF7, which is a generally expressed component of TFIID. Here we report the generation of Taf7l mutant mice by homologous recombi...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-5510 | biostudies-arrayexpress
Sort   by:  
 Page size