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TranscriptomicsTranscription profiling of mouse Scl -/- yolk sac cell line after reintroduction of Scl by protein transduction
Expression profile of Scl -/- yolk sac cell line after reintroduction of Scl
ORGANISM(S): Mus musculus 
2008-01-09 | E-TABM-397 | biostudies-arrayexpress
TranscriptomicsScl-Ab: Exploratory 26-Week Subcutaneous Toxicology Study in the Aged Ovariectomized Female Sprague Dawley Rat with an 18-week Recovery
This study is designed to compare and contrast the temporal and spatial changes in bone formation rates and transcriptional profiles in cortical and cancellous bone cell populations enriched by laser capture microdissection (LCM) in ovariectomized rats administered Scl-Ab by subcutaneous injection f...
ORGANISM(S): Rattus norvegicus 
2016-01-06 | E-GEOD-71306 | biostudies-arrayexpress
ProteomicsAffinity Purification Mass Spectrometry of protein protein interactors with alternatively-spliced Uromodulin
We identified an alternatively spliced UMOD which is uniquely localized intracellularly. This intracellular isoform enhanced mitochondrial function. To understand its molecular mechanism, we performed affinity-purification coupled to mass spectrometry using MDCK cell lysate expressing UMOD variant. ...
ORGANISM(S): Canis Lupus Familiaris (ncbitaxon:9615) Homo Sapiens (ncbitaxon:9606) 
2024-03-15 | MSV000094329 | MassIVE
TranscriptomicsRNA-seq of mouse Embryonic Stem Cell (mESC) line-derived endothelial and hematopoietic cells subjected to differential doxycycline (dox)-induced expression of transcription factors (TFs) in a Tal1Δ/Δ genetic background
RNA-seq of endothelial (Endo), Pre-hematopoietic progenitor cells (Pre-HPCs) and hematopoietic progenitors (HP) derived from the in-vitro hematopoietic differentiation of mouse Embryonic Stem Cells (mESCs) harboring a biallelic inactivating deletion of the endogenous Tal1 gene, and a construct for t...
ORGANISM(S): Mus musculus 
2023-05-15 | E-MTAB-12973 | biostudies-arrayexpress
TranscriptomicsA study of the differentiation of Murine ES cells [Scl+/hCD4 ES cells (Chung et al., 2002)] into hemangioblasts
Molecular mechanisms that regulate the generation of hematopoietic and endothelial cells from mesoderm are poorly understood. To define the underlying mechanisms, we compared gene expression profiles between embryonic stem (ES) cell-derived hemangioblasts (Blast-Colony-Forming Cells, BL-CFCs) and th...
ORGANISM(S): Mus musculus 
2007-01-25 | E-GEOD-6835 | biostudies-arrayexpress
TranscriptomicsATAC-seq of mouse Embryonic Stem Cell (mESC) line-derived cells subjected or not to doxycycline (dox)-induced overexpression of transcription factors
The ATAC-seq is one of three readouts of an experiment carried out to assess the ability of different combinations of hematopoietic transcription factors to elicit the transdifferentiation of a mESC-derived non-hematopoietic cell type (vascular smooth muscle cells) into hematopoietic precursors upon...
ORGANISM(S): Mus musculus 
2023-05-08 | E-MTAB-12955 | biostudies-arrayexpress
TranscriptomicsRNA-seq of mouse Embryonic Stem Cell (mESC) line-derived cells subjected or not to doxycycline (dox)-induced overexpression of transcription factors (TFs)
The RNA-seq is one of three readouts of an experiment carried out to assess the ability of different combinations of hematopoietic transcription factors to elicit the transdifferentiation of a mESC-derived non-hematopoietic cell type (vascular smooth muscle cells) into hematopoietic precursors upon ...
ORGANISM(S): Mus musculus 
2023-05-15 | E-MTAB-12957 | biostudies-arrayexpress
TranscriptomicsDivergent functions of hematopoietic transcription factors in lineage priming and differentiation during erythro-megakaryopoiesis
Combinatorial actions of relatively few transcription factors control hematopoietic differentiation. To investigate this process in erythro-megakaryopoiesis, we correlated the genome-wide chromatin occupancy signatures of four master hematopoietic transcription factors (GATA1, GATA2, SCL/TAL1 and FL...
ORGANISM(S): Mus musculus 
2013-08-09 | E-GEOD-49664 | biostudies-arrayexpress
TranscriptomicsDivergent functions of hematopoietic transcription factors in lineage priming and differentiation during erythro-megakaryopoiesis
Combinatorial actions of relatively few transcription factors control hematopoietic differentiation. To investigate this process in erythro-megakaryopoiesis, we correlated the genome-wide chromatin occupancy signatures of four master hematopoietic transcription factors (GATA1, GATA2, TAL1, and FLI1)...
ORGANISM(S): Mus musculus 
2014-11-14 | E-GEOD-51337 | biostudies-arrayexpress
TranscriptomicsGene expression studies of a human monocyte cell line identify dissimilarities between Copaxone and Probioglat
Glatiramer Acetate (GA) has provided safe and effective treatment for multiple sclerosis (MS) patients for two decades. It acts as an antigen, yet the precise mechanism of action remains to be fully elucidated, and no validated pharmacokinetic or pharmacodynamic biomarkers exist. In order to bette...
ORGANISM(S): Homo sapiens 
2015-05-22 | E-GEOD-68527 | biostudies-arrayexpress
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