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TranscriptomicsPotential capacity of aptamers to trigger immune activation in human blood
Target specific short single-stranded DNA (ssDNA) molecules, called aptamers, are auspicious ligands for numerous in vivo applications. However, aptamers are synthetic molecules, which might be recognized by the immune cells in vivo and induce an activation of the innate immune system. Thus, immune ...
ORGANISM(S): Homo sapiens 
2013-05-07 | E-GEOD-46676 | biostudies-arrayexpress
TranscriptomicsTranscriptional responses of resistant and susceptible fish clones to the bacterial pathogen Flavobacterium psychrophilum
Comparison of the transcriptional response to the bacteria in the pronephros of a susceptible and a resistant line by micro-array analysis five days after infection Four to seven individual fishes have been analyzed for each experimental condition : Infected or Control ; Susceptible or resistant lin...
ORGANISM(S): Oncorhynchus mykiss 
2013-01-02 | E-GEOD-35448 | biostudies-arrayexpress
MetabolomicsIdentification of chemotypes in bitter melon by metabolomics: a plant with potential benefit for management of diabetes in traditional Chinese medicine

INTRODUCTION: Bitter melon (Momordica charantia, Cucurbitaceae) is a popular edible medicinal plant, which has been used as a botanical dietary supplement for the treatment of diabetes and obesity in Chinese folk medicine. Previously, our team has proved that cucurbitanes triterp...

2019-10-24 | MTBLS701 | MetaboLights
TranscriptomicsNo accelerated rate of protein evolution in male biased Drosophila pseudoobscura genes
Sexually dimorphic traits are subject to diversifying selection. Also genes with a male biased gene expression are probably affected by sexual selection and have a high rate of protein evolution. We used SAGE to measure sex biased gene expression in Drosophila pseudoobscura. Consistent with previous...
ORGANISM(S): Drosophila pseudoobscura 
2006-07-27 | E-GEOD-2840 | biostudies-arrayexpress
TranscriptomicsT cell help controls the speed of the cell cycle in germinal center B cells.
The germinal center (GC) is a microanatomical compartment wherein high-affinity antibody-producing B cells are selectively expanded. B cells proliferate and mutate their antibody genes in the dark zone (DZ) of the GC and are then selected by T cells in the light zone (LZ) on the basis of affinity. H...
ORGANISM(S): Mus musculus 
2015-08-12 | E-GEOD-71295 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human mononuclear cells from acute megakaryoblastic leukemia with and without Down syndrome
mononuclear cells were isolated on a density gradient and RNA extracted using Trizol and the Promega SV column RNA purification. Affymetrix U133A chips were hybridised using standard procedures at the core facility of Dana Farber Cancer Institute. Experiment Overall Design: This series includes samp...
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-4119 | biostudies-arrayexpress
TranscriptomicsEpigenetic targeting of activation-induced cytidine deaminase
Precisely how AID is recruited to these off-target sites is not entirely understood. To gain further insight into how AID selects its targets we compared AID-mediated translocations in two different cell types, B cells and mouse embryonic fibroblasts (MEFs). AID targets a distinct set of hotspots in...
ORGANISM(S): Mus musculus 
2015-01-30 | E-GEOD-61523 | biostudies-arrayexpress
TranscriptomicsBT549 cells depleted of ELP3 compared to control
Understand the proteome dependent on the mcm5s2 U34 tRNA modification in breast cancer
ORGANISM(S): Homo sapiens 
2020-06-20 | E-MTAB-9206 | biostudies-arrayexpress
TranscriptomicsGenome-wide copy number analysis of patient-derived gliobastoma cell cultures
Genome-wide copy number variation profiles were analyzed in the patient-derived gliobastoma cell culture samples. For this purpose, gDNA was analyzed using the CytoScan® assay in combination with a one-color based labeling and hybridization protocol. Signals on the CytoScan® HD microarrays were dete...
ORGANISM(S): Homo sapiens 
2019-02-28 | E-MTAB-7649 | biostudies-arrayexpress
TranscriptomicsDifferential gene expression in thrombus-derived white blood cells of patients with acute coronary syndrome
Inflammatory mechanisms and immune cells are involved in acute coronary syndromes (ACS) and may lead to acute plaque rupture. However, the local expression of the different genes potentially involved is largely unknown. We therefore performed an Affymetrix analysis of genes expressed in white blood ...
ORGANISM(S): Homo sapiens 
2011-12-04 | E-GEOD-19339 | biostudies-arrayexpress
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