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ProteomicsAnimal product-free culture conditions for 3D primary human hepatocyte spheroids improve long-term viability and drug metabolism
3D cultures of primary human hepatocytes (3D PHH) are successfully used to reduce and replace the use of animal experiments in biomedical research. Yet, the initial formation of 3D PHH is highly dependent on the supplementation with fetal bovine serum (FBS). However, the molecular composition of FBS...
ORGANISM(S): Homo sapiens (Human) 
2026-01-23 | PXD056428 | Pride
Human Setum-free Fbs Liver 3d phh 
ProteomicsOCT1 (SLC22A1) transporter kinetics and regulation in primary human hepatocyte 3D spheroids
3D spheroids of primary human hepatocytes (3D PHH) keep a differentiated phenotype with retained metabolic function and proteome fingerprint for weeks in culture. As a result, 3D PHH are gaining ground as a model for mechanistic studies on liver homeostasis and in vitro to in vivo (IVIV)predictions...
ORGANISM(S): Homo sapiens (Human) 
2024-08-10 | PXD045733 | Pride
Human Hepatocytes Adme Liver 
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