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MetabolomicsMulti-omics analysis reveals microbiota-metabolite crosstalk in MASLD pathogenesis in a non-obese murine model

The rising global prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD), including its severe form metabolic dysfunction-associated steatohepatitis (MASH), underscores the urgency to elucidate its pathophysiology. To investigate key metabolic interactions central to MASLD...

2026-03-13 | MTBLS14048 | MetaboLights
MetabolomicsMulti-omics analysis identifies gut microbiota-glutamine axis contributing to the pathogenesis of reflux esophagitis

Background: Reflux esophagitis (RE), a common gastroesophageal reflux disease characterized by esophageal mucosal inflammation, is closely associated with gut microbiota dysbiosis and metabolic abnormalities. The glutamine-glutamate metabolic pathway regulates inflammation and mucosal barrier fun...

2026-05-03 | MTBLS14421 | MetaboLights
MetabolomicsChanges in the Abundance of the Fecal Microbiota are Implicated in the Pathogenesis of Diarrhea in Yak Calves

The yak, an economically vital species on the Qinghai-Tibet Plateau, faces a significant challenge with diarrhea during the calf stage. However, studies about diarrhea of yak calves were few. Due to the close link between diarrhea and intestinal microbiota. Therefore, this study analyzed the feca...

2026-06-03 | MTBLS13964 | MetaboLights
MetabolomicsA synthetic community system for probing microbial interactions driven by exometabolites
Despite that most microorganisms live as part of community, we have modest knowledge about the interactions among microbial community members in nature, and the implications of those interactions for emergent community properties or ecosystem-relevant functions. To facilitate advances in understandi...
2017-10-26 | MTBLS525 | MetaboLights
MetabolomicsStage-specific roles of microbial dysbiosis and metabolic disorders in rheumatoid arthritis

OBJECTIVE: Rheumatoid arthritis (RA) is a progressive disease including four stages, where gut microbiome is associated with pathogenesis. We aimed to investigate stage-specific roles of microbial dysbiosis and metabolic disorders in RA.

METHODS: We investi...

2023-01-31 | MTBLS5297 | MetaboLights
MetabolomicsIntegrated Gut Microbiome and Metabolomics Analysis Reveals Microbial-Metabolic Cross-talk in Allergic Rhinitis

Background: Emerging evidence indicates a link between gut dysbiosis and allergic rhinitis (AR) pathogenesis. Nevertheless, the mechanistic role of gut microbiota in AR progression requires further characterization. To address this, we employed an integrated multi-omics strategy to delineat...

2025-09-22 | MTBLS13021 | MetaboLights
MetabolomicsGut Microbial Genes and Metabolism for Methionine and Branched-Chain Amino Acids in Diabetic Nephropathy

Diabetic mellitus nephropathy (DMN) is a serious complication of diabetes and a major health concern. Although the pathophysiology of diabetes mellitus (DM) leading to DMN is uncertain, recent evidence suggests the involvement of the gut microbiome. This study aimed to determine the relationships...

2023-03-01 | MTBLS6331 | MetaboLights
MetabolomicsGut Microbial and Metabolic Responses to Salmonella enterica Serovar Typhimurium and Candida albicans

The gut microbiota is increasingly recognized for playing a critical role in human health and disease, especially in conferring resistance to both virulent pathogens such as Salmonella, which infects 1.2 million people in the United States every year [1], and opportunistic pathogens like Candida,...

2019-09-20 | MTBLS753 | MetaboLights
MetabolomicsMicrobial tryptophan metabolism orchestrated by trilobatin through TPH1 activation protects against acute kidney injury
Background: Acute kidney injury (AKI) remains a major clinical challenge with limited therapeutic options. Gut microbiota dysbiosis plays a crucial role in the pathogenesis of AKI. Trilobatin (TLB), has been previously reported to modulate gut microbiota and exert neuroprotective effects; however, i...
2026-04-05 | MTBLS14222 | MetaboLights
UnknownTransport proteins promoting Escherichia coli pathogenesis.
Not available
S-EPMC4106412 | biostudies-literature
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