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MetabolomicsComparative metabolomic analysis of exudates of microcystin-producing and microcystin-free Microcystis aeruginosa strains

Cyanobacterial harmful algal blooms (cHABs) dominated by Microcystis aeruginosa threaten the ecological integrity and beneficial uses of lakes globally. In addition to producing hepatotoxic microcystins (MC), M. aeruginosa exudates (MaE) contain various compounds with demonstrat...

2023-01-16 | MTBLS6603 | MetaboLights
TranscriptomicsTranscription profiling of zebrafish larvae exposed to microcystin
Zebrafish (Danio rerio) were obtained from the Zebrafish Research Facility maintained in the Center for Environmental Biotechnology at the University of Tennessee. Fish husbandry, spawning, and experimental procedures were conducted with approval from the University of Tennessee Institutional Anima...
ORGANISM(S): Danio rerio 
2009-08-07 | E-GEOD-12214 | biostudies-arrayexpress
TranscriptomicsMicroarray Analysis of Microcystin-LR
Microcystins are produced by the cyanobacteria, most commonly Microcystis aerµginosa. Upon ingestion, toxic microcystins are actively absorbed by fish, birds and mammals where they are primarily liver toxins. Groups of 4-6 rats were exposed to 0, 1, 10, 50 or 100 µg/kg microcystin-LR for 0.5, 1, 3 o...
ORGANISM(S): Rattus norvegicus 
2014-07-25 | E-GEOD-59495 | biostudies-arrayexpress
ProteomicsMicrocystin-LR activates serine/threonine kinases and alters the phosphoproteome in human HepaRG cells
Microcystin-LR (MCLR) exposure has been associated with development of hepatocellular carcinoma (HCC). Many of the carcinogenic mechanisms for MCLR have been attributed to the induction of cell survival and proliferation through altered protein phosphorylation pathways by inhibition of protein phosp...
ORGANISM(S): Homo sapiens (Human) 
2025-02-05 | PXD054405 | Pride
Protein phosphatase Mitogen-activated protein kinase Microcystin-lr Protein phosphorylation Phosphoproteomics Heparg cells 
TranscriptomicsTranscriptional and Behavioral Responses of Zebrafish Larvae to Microcystin-LR Exposure
Microcystin-LR (MC-LR), the most toxic member of microcystin family, inhibits protein phosphatase PP2A, triggers oxidative stress and induces hepatotoxicity. Gene expression profiling of MC-LR treated larvae using DNA microarray analysis revealed effects in the retinal visual cycle and pigmentation ...
ORGANISM(S): Danio rerio 
2017-02-16 | GSE73739 | GEO
UnknownMicrocystin mcyA and mcyE Gene Abundances Are Not Appropriate Indicators of Microcystin Concentrations in Lakes.
Not available
S-EPMC4422731 | biostudies-literature
UnknownIdentifying the source of unknown microcystin genes and predicting microcystin variants by comparing genes within uncultured cyanobacterial cells.
Not available
S-EPMC2687263 | biostudies-literature
UnknownInfluence of temperature, mixing, and addition of microcystin-LR on microcystin gene expression in Microcystis aeruginosa.
Not available
S-EPMC5300888 | biostudies-literature
TranscriptomicsTranscriptome analysis of Novosphingobium sp. THN1 during microcystin-LR degradation under different carbon concentrations
The bacterium Novosphingobium sp. THN1 (THN1) is capable of degrading microcystin-LR (MCLR). To get an insight into genes expression during MCLR degradation and the regulation of different carbon concentrations on MCLR degradation, we performed RNA-seq of THN1 during MCLR degradation under different...
ORGANISM(S): Novosphingobium sp. THN1 
2019-01-30 | GSE125827 | GEO
GenomicsAlteration of MicroRNA Expression Profile Linked to Microcystin-LR-Induced Tumorigenicity in Human WRL-68 Cell Line
We report microcystin-LR, a cyclic heptapeptide that acts as a potent hepatotoxin and carcinogen, was used to induce the malignant transformation of the WRL-68 cell line and alterations in microRNA (miRNA) expression in the transformed cells.
ORGANISM(S): Murid gammaherpesvirus 4 Human gammaherpesvirus 8 Homo sapiens Mus musculus Human alphaherpesvirus 1 Human betaherpesvirus 5 Murid betaherpesvirus 1 Human immunodeficiency virus 1 Rattus norvegicus JC polyomavirus Betapolyomavirus hominis human gammaherpesvirus 4 Betapolyomavirus macacae 
2012-07-31 | GSE30560 | GEO
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