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TranscriptomicsMicroarray Analysis of Microcystin-LR
Microcystins are produced by the cyanobacteria, most commonly Microcystis aerµginosa. Upon ingestion, toxic microcystins are actively absorbed by fish, birds and mammals where they are primarily liver toxins. Groups of 4-6 rats were exposed to 0, 1, 10, 50 or 100 µg/kg microcystin-LR for 0.5, 1, 3 o...
ORGANISM(S): Rattus norvegicus 
2014-07-25 | E-GEOD-59495 | biostudies-arrayexpress
ProteomicsMicrocystin-LR activates serine/threonine kinases and alters the phosphoproteome in human HepaRG cells
Microcystin-LR (MCLR) exposure has been associated with development of hepatocellular carcinoma (HCC). Many of the carcinogenic mechanisms for MCLR have been attributed to the induction of cell survival and proliferation through altered protein phosphorylation pathways by inhibition of protein phosp...
ORGANISM(S): Homo sapiens (Human) 
2025-02-05 | PXD054405 | Pride
Protein phosphatase Mitogen-activated protein kinase Microcystin-lr Protein phosphorylation Phosphoproteomics Heparg cells 
TranscriptomicsTranscriptional and Behavioral Responses of Zebrafish Larvae to Microcystin-LR Exposure
Microcystin-LR (MC-LR), the most toxic member of microcystin family, inhibits protein phosphatase PP2A, triggers oxidative stress and induces hepatotoxicity. Gene expression profiling of MC-LR treated larvae using DNA microarray analysis revealed effects in the retinal visual cycle and pigmentation ...
ORGANISM(S): Danio rerio 
2017-02-16 | GSE73739 | GEO
GenomicsDifferentially expressed genes in the livers of mice exposed to microcystin-LR (MC-LR)
Differentially expressed genes in the livers of mice exposed to microcystin-LR (MC-LR)
PRJNA607252 | ENA
TranscriptomicsTranscriptome analysis of Novosphingobium sp. THN1 during microcystin-LR degradation under different carbon concentrations
The bacterium Novosphingobium sp. THN1 (THN1) is capable of degrading microcystin-LR (MCLR). To get an insight into genes expression during MCLR degradation and the regulation of different carbon concentrations on MCLR degradation, we performed RNA-seq of THN1 during MCLR degradation under different...
ORGANISM(S): Novosphingobium sp. THN1 
2019-01-30 | GSE125827 | GEO
GenomicsTranscriptome analysis of Novosphingobium sp. THN1 during microcystin-LR degradation under different carbon concentrations
Transcriptome analysis of Novosphingobium sp. THN1 during microcystin-LR degradation under different carbon concentrations
PRJNA517658 | ENA
GenomicsAlteration of MicroRNA Expression Profile Linked to Microcystin-LR-Induced Tumorigenicity in Human WRL-68 Cell Line
We report microcystin-LR, a cyclic heptapeptide that acts as a potent hepatotoxin and carcinogen, was used to induce the malignant transformation of the WRL-68 cell line and alterations in microRNA (miRNA) expression in the transformed cells.
ORGANISM(S): Murid gammaherpesvirus 4 Human gammaherpesvirus 8 Homo sapiens Mus musculus Human alphaherpesvirus 1 Human betaherpesvirus 5 Murid betaherpesvirus 1 Human immunodeficiency virus 1 Rattus norvegicus JC polyomavirus Betapolyomavirus hominis human gammaherpesvirus 4 Betapolyomavirus macacae 
2012-07-31 | GSE30560 | GEO
UnknownMicrocystin-LR (MC-LR) Triggers Inflammatory Responses in Macrophages.
Not available
S-EPMC8472269 | biostudies-literature
TranscriptomicsEffect of Microcystin-LR and cylindrospermopsin (CYN) on gene expression in human hepatocytes, HepaRG cells and HCC HepG2 cells.
Human hepatocytes, HepaRG cells and HCC HepG2 cells were treated with 50nM of Microcystin-LR and cylindrospermopsin (CYN) to observe changes in gene expression.
ORGANISM(S): Homo sapiens 
2023-05-12 | E-MTAB-12881 | biostudies-arrayexpress
GenomicsEffect of Microcystin-LR and cylindrospermopsin (CYN) on gene expression in human hepatocytes, HepaRG cells and HCC HepG2 cells.
Effect of Microcystin-LR and cylindrospermopsin (CYN) on gene expression in human hepatocytes, HepaRG cells and HCC HepG2 cells.
PRJEB61791 | ENA
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