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Microtubule actin crosslinking factor 1 (Macf1) plays a role in coordinated actions of actin and microtubules in multiple cellular processes. Here we show that Macf1 is also critical for ciliogenesis in multiple cell types. Ablation of Macf1 in the developing retina abolishes ciliogenesis and basal ...
ORGANISM(S): Mus musculus 
2016-11-01 | GSE86997 | GEO
Controlled myogenic differentiation is integral to the development, maintenance and repair of skeletal muscle, necessitating precise regulation of myogenic progenitors and resident stem cells. The transformation of proliferative muscle progenitors into multinuclear syncytia involves intricate cellul...
ORGANISM(S): Mus musculus 
2024-07-17 | GSE272316 | GEO
Cilia are essential motile or sensory organelles found on many eukaryotic cells. Their formation and function rely on axonemal microtubules, which exhibit very slow dynamics, however the underlying biochemical mechanisms are largely unexplored. Here, we reconstituted in vitro the individual and coll...
ORGANISM(S): Homo sapiens (Human) 
2024-11-19 | PXD055631 | Pride
Analysis of deregulated genes upon Septin9 depletion in C2C12 and primary isolated myoblasts
Loss of Macf1 abolishes ciliogenesis and disrupts apicobasal polarity establishment in the retina
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