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MetabolomicsProtein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase

Metabolic networks are interconnected and influence diverse cellular processes. The protein-metabolite interactions that mediate these networks are frequently low affinity and challenging to systematically discover. We developed mass spectrometry integrated with equilibrium dialysis for the disco...

2023-08-07 | MTBLS7237 | MetaboLights
GenomicsMidas v5
Midas genome assembly version 5
PRJEB6974 | ENA
ModelsSizek2023 - Mitochondrial Dysfunction-Associated Senescence (MiDAS) with cell cycle and apoptosis
This 133-node Boolean regulatory network model reproduces mitochondrial dynamics during cell cycle progression (hyper-fusion at the G1/S boundary, fission in mitosis), apoptosis (fission and dysfunction) and glucose starvation (reversible hyper-fusion), as well as MiDAS in response to SIRT3 knockdow...
2024-08-26 | MODEL2312140001 | BioModels
OtherMiDAS in BRCA2-deficient cells originate at early S-phase transcription-replication conflicts
Multiple replication abnormalities cause cells lacking BRCA2 to enter mitosis with under-replicated DNA and to activate mitotic DNA synthesis (MiDAS). However, the precise position of these MiDAS sites, as well as their origin, remains unknown. Here we labelled mitotic nascent DNA and performed high...
ORGANISM(S): Homo sapiens 
2022-08-01 | GSE196163 | GEO
OtherAtypical mitotic DNA synthesis sequencing (MiDAS-seq) in U2OS cells depleted for RAD51
DNA replication stress is an established driver of cancer-associated chromosomal rearrangements. Replication stress perturbs the duplication of late-replicating loci and activates a mitotic DNA repair pathway (termed MiDAS) for completion of replication. We here investigated RAD51-independent MiDAS.
ORGANISM(S): Homo sapiens 
2022-06-27 | GSE196278 | GEO
GenomicswtAmpMida
Amphicteis midas (golden head worm), wtAmpMida
PRJEB107286 | ENA
GenomicsMiDAS in BRCA2-deficient cells originate at early S-phase transcription-replication conflicts
MiDAS in BRCA2-deficient cells originate at early S-phase transcription-replication conflicts
PRJNA803497 | ENA
GenomicsAtypical mitotic DNA synthesis sequencing (MiDAS-seq) in U2OS cells depleted for RAD51
Atypical mitotic DNA synthesis sequencing (MiDAS-seq) in U2OS cells depleted for RAD51
PRJNA804143 | ENA
GenomicswtAmpMida1
Amphicteis midas (golden head worm) genome assembly, wtAmpMida1
PRJEB114428 | ENA
ProteomicsPrey killing without invasion by Bdellovibrio bacteriovorus defective for a MIDAS-family adhesin
The experimental project studied a MIDAS adhesin minus mutant of predatory bacterium B. bacteriovorus.The predatory bacterium normally invades and lives inside E.coli bacteria, rounding them up to form a two-bacterial structure, called a bdelloplast, and killing the E.coli from the inside. However ...
ORGANISM(S): Bdellovibrio bacteriovorus HD100 
2024-03-18 | PXD050423 | Pride
Proteomics Ecoli Empty bdelloplasts B. bacteriovorus 
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