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MetabolomicsLong-term metabolic profiling in transient middle cerebral artery occlusion (tMCAO) mouse model
Not available
ORGANISM(S): Mus musculus 
ST002042 | MetabolomicsWorkbench
TranscriptomicsTranscription profiling of mouse forebrain with induced middle cerebral artery occlusion (MCAO) to study permanent focal cerebral ischemia
profiling gene transcription in a mouse model of permanent focal cerebral ischemia that was induced by middle cerebral artery occlusion (MCAO)
ORGANISM(S): Mus musculus 
2009-03-07 | E-TABM-655 | biostudies-arrayexpress
MetabolomicsIntegrated multi-omics reveals gut microbiota–metabolic mechanisms underlying the neuroprotective effects of Xijiao Dihuang Decoction against cerebral ischemia–reperfusion injury
This study investigated the effects of Xijiao Dihuang Decoction (XDD) on cerebral ischemia–reperfusion injury using a middle cerebral artery occlusion/reperfusion rat model. Untargeted LC–MS metabolomics was performed on fecal samples to characterize metabolic alterations associated with MCAO/R and ...
2026-09-23 | MTBLS15783 | MetaboLights
TranscriptomicsGlobal transcriptomic profiling of ischemic/reperfusion injury in an in vivo wild-type mouse model.
Ischemic stroke triggers severe focal hypoperfusion accompanied with deprivation of oxygen and glucose to the cerebral tissue, together with loss of ATP, depolorization of neurons, elevated extracellular potassium concentration, and subsequently leads to excitotoxicity as well as increased oxidative...
ORGANISM(S): Mus musculus 
2011-01-10 | E-GEOD-23160 | biostudies-arrayexpress
TranscriptomicsIdentification of new therapeutic targets by genome-wide analysis of gene expression in the ipsilateral cortex of aged rats after stroke
Because most human stroke victims are elderly, studies of experimental stroke in the aged rather than the young rat model may be optimal for identifying clinically relevant cellular responses, as well for pinpointing beneficial interventions. We employed the Affymetrix platform to analyze the whole-...
ORGANISM(S): Rattus norvegicus 
2014-04-22 | E-GEOD-55260 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of in rat brains 6-48 hours after MCAO stroke incudtion with and without FK506 drug treatment
Analysis of changes in gene expression induced by a transient (90') middle cerebral artery occulsion, at several time points post stroke induction, with the effect of a treatment with the drug FK506 studied at a single time point.
ORGANISM(S): Rattus norvegicus 
2010-06-19 | E-MEXP-2222 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of white and grey matter in the distribution on the middle cerebral artery 6 hours after administration of the saline/catalytic antioxidant AEOL 10150 and ischemia/reperfusion of the MCAO to study the effect of AEOL 10150 on gene expression.
A catalytic antioxidant (AEOL 10150) attenuates expression of inflammatory genes in stroke. White and grey matter in the distribution on the middle cerebral artery 6 hours after administration of the saline/catalytic antioxidant AEOL 10150 and ischemia/reperfusion of the MCAO; pooled mRNA from 6 bra...
ORGANISM(S): Mus musculus 
2007-12-15 | E-GEOD-63 | biostudies-arrayexpress
MetabolomicsTherapeutic Effect of Buyang Huanwu Decoction on the Gut Microbiota and Hippocampal Metabolism in a Rat Model of Cerebral Ischemia

Buyang Huanwu decoction (BHD) is a well-known Chinese herbal prescription. It has been widely used in the clinical treatment of cerebral ischemia (CI) in China. However, the mechanism underlying the treatment of CI with BHD remains to be elucidated. In this study, we combined microbiomic and meta...

2022-06-02 | MTBLS4366 | MetaboLights
TranscriptomicsGlobal transcriptomic profiling of ischemic/reperfusion injury in an in vivo Gpx1 -/- transgenic mouse model.
Glutathione peroxidase (Gpx) is a selenium-containing enzyme that catalyses the reduction of a variety of biological peroxides at the expense of reduced glutathione (GSH). Gpx1 is the most abundant isoform and its role has been implicated in neurodegenerative disorders such as ParkinsonM-bM-^@M-^Ys ...
ORGANISM(S): Mus musculus 
2011-01-10 | E-GEOD-23162 | biostudies-arrayexpress
GenomicsSmall RNA sequencing of mouse brain after middle cerebral artery occlusion
Small RNA sequencing of mouse brain after middle cerebral artery occlusion
PRJNA889372 | ENA
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