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UnknownDihydroxyacetone suppresses mTOR nutrient signaling and induces mitochondrial stress in liver cells.
Not available
S-EPMC9725129 | biostudies-literature
UnknownSolution Chemistry of Dihydroxyacetone and Synthesis of Monomeric Dihydroxyacetone.
Not available
S-EPMC9020455 | biostudies-literature
MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Cell NAMPTi treatment)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7251 | MetaboLights
MetabolomicsNicotinamide Riboside is Uniquely Bioavailable in People and Mice
Nicotinamide riboside (NR) is in wide use as an NAD+ precursor vitamin. Here we conducted experiments to determine the time and dose-dependent effects of NR on blood, liver and heart NAD+ metabolism in people and mice. We report that human blood cell NAD+ can rise as much as 2.7-fold with a single d...
2016-09-09 | MTBLS368 | MetaboLights
MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Mouse NAMPT targeted therapy)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7252 | MetaboLights
MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Mouse NAD targeted time-course)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7253 | MetaboLights
ProteomicsData files for manuscript "NAD precursors cycle between host tissues and the gut microbiome"
These are the raw mass spec data files for manuscript "NAD precursors cycle between host tissues and the gut microbiome", Karthikeyani Chellappa et al. Check out "Mass Spec data_KEY_Chellappa et al Cell Metabolism_2022.xlsx" for data file arrangement.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-10-06 | MSV000090481 | MassIVE
UnknownNicotinamide Riboside and Dihydronicotinic Acid Riboside Synergistically Increase Intracellular NAD+ by Generating Dihydronicotinamide Riboside.
Not available
S-EPMC9269339 | biostudies-literature
UnknownInherited CARD9 deficiency in 2 unrelated patients with invasive Exophiala infection.
Not available
S-EPMC4447834 | biostudies-literature
UnknownTargeting the autophagy-NAD axis protects against cell death in Niemann-Pick type C1 disease models.
Not available
S-EPMC11143325 | biostudies-literature
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