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TranscriptomicsNucleoredoxin is required for the maintenance of Wnt/β-catenin signaling in mice embryo
We previously showed that nucleoredoxin (NRX) suppresses Wnt/β-catenin signaling through its binding to Dishevelled (Dvl) (Nat Cell Biol 8, 501-508 (2006)). To clarify the in vivo role of NRX in mammals, we here generate NRX gene-knockout mice (NRX-/- mice) by homologous recombination. NRX-/- mice ...
ORGANISM(S): Mus musculus 
2010-10-26 | E-GEOD-21954 | biostudies-arrayexpress
GenomicsWhole genome bisulfite sequencing of idm1, rdd, ros1 mutants and Col-0 WT
Using whole genome bisulfite sequencing to provide single-base resulution of DNA methylation status in ros1, idm1, and rdd mutants and identify hypermethylated regions comparing to wild type Arabidopsis plants. Examination of 3 different mutants' methylome. 8 samples (3 mutants, 1 WT, each has two b...
ORGANISM(S): Arabidopsis thaliana 
2012-06-17 | E-GEOD-33071 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis roots from wild type and stop1 mutant plants treated with Al or low pH
Comparison of stop1 mutant vs. wild type treated with Al or low pH, and gene expression responses to rhizotoxic ions (Al, low pH) in Arabidopsis roots.
ORGANISM(S): Arabidopsis thaliana 
2009-05-04 | E-MEXP-1908 | biostudies-arrayexpress
GenomicsWhole genome bisulfite sequencing of rdm16ros1, ros1, nrpd1ros1 mutants and C24 wild-type
Using whole genome bisulfite sequencing to provide single-base resulution of DNA methylation status in rdm16ros1, ros1, nrpd1ros1 mutants and examine the effect of RDM16 on DNA methylation 4 samples examined: C24 wild type with RD29A-LUC transgene, rdm16ros1 double mutant, ros1 mutant, nrpd1ros1 mut...
ORGANISM(S): Arabidopsis thaliana 
2013-09-27 | E-GEOD-44417 | biostudies-arrayexpress
TranscriptomicsMeDIP-chip of zdp mutant
Using meDIP-chip to provide methylation profile in zdp mutant and identify hypermethylated regions comparing to wild type Arabidopsis plants. Examination of zdp mutant's methylome. 4 samples(1 mutant, 1 WT, each has two biological replicates)
ORGANISM(S): Arabidopsis thaliana 
2012-03-20 | E-GEOD-33719 | biostudies-arrayexpress
GenomicsMethlyC-Seq of wild type (with 35S-SUC2 transgene) and idm3-1, mbd7-1 mutants (same 35S-SUC2 background)
In eukaryotes, heterochromatin is characterized by numerous epigenetic marks, including DNA methylation. Spreading of these marks into nearby active genes must be avoided in order to maintain appropriate gene expression. Here, we uncover Arabidopsis Methyl-CpG-Binding Domain 7 (MBD7) and Increased D...
ORGANISM(S): Arabidopsis thaliana 
2015-01-29 | E-GEOD-58787 | biostudies-arrayexpress
GenomicsChIP-seq of WT(with 35S-SUC2 transgene) and proMBD7::gMBD7:4xMYC transgenic plants
In eukaryotes, heterochromatin is characterized by numerous epigenetic marks, including DNA methylation. Spreading of these marks into nearby active genes must be avoided in order to maintain appropriate gene expression. Here, we uncover Arabidopsis Methyl-CpG-Binding Domain 7 (MBD7) and Increased D...
ORGANISM(S): Arabidopsis thaliana 
2015-01-29 | E-GEOD-58789 | biostudies-arrayexpress
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