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ProteomicsIntegrating intracellular and extracellular proteomic profiling for in-depth investigations of cellular communication in a model of prostate cancer
Cellular communication is essential for cell-cell interactions, maintaining homeostasis and progression of certain disease states. While many studies examine extracellular proteins, the holistic extracellular proteome is often left uncaptured, leaving gaps in our understanding of how all extracellul...
ORGANISM(S): Homo sapiens (Human) 
2023-05-25 | PXD037806 | Pride
Prostate cancer Extracellular proteomics Lc-ms/ms 
TranscriptomicsTranscriptome of mouse erythroid cells (part1) poly(A)+
We report genome-wide maps of transcription in mouse erythroid cells. We used an approach to survey poly(A)+ (mRNA) (GSE26877) and non-polyadenylated RNA poly(A)- (GSE27920) separately. This provides an alternative framework for comprehensive transcriptome profiling in mammalian cells. Two Samples. ...
ORGANISM(S): Mus musculus 
2012-01-30 | E-GEOD-26877 | biostudies-arrayexpress
ProteomicsProtein profiling of stress-activated breast cancer cell models
This study provides insights into the efficacy of beta-blockers as breast cancer therapeutics.Cell line models of basal-type and estrogen receptor-positive breast cancer were profiled for basal levels of adrenoceptor gene/protein expression, and ADRβ2-mediated cell behaviour including migration, inv...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD009488 | Pride
Breast cancer Lc-msms Swath Human 
TranscriptomicsMapping the cellular and molecular landscape of cardiac non-myocytes in murine type-2 diabetes
Here we define key single-cell transcriptional alterations within cardiac non-myocytes, from ventricles of spontaneously type-2 diabetic (db/db) and control (db/h) mouse hearts ([B6.BKS(D)-Lepr/J], stock #000697). The cell preparation sequenced consisted of metabolically active, live and nucleat...
ORGANISM(S): Mus musculus 
2022-11-29 | E-MTAB-11940 | biostudies-arrayexpress
TranscriptomicsCorn under weed, low nitrogen, and shade stress
This study was designed to identify changes in gene expression when corn was placed under various related stresses including being grown with a competing weed (canola) to the V4 or V8 stage, or when 40% shade cloth was present to the V4 or V8 stage, or under low nitrogen (no added nitrogen fertiliz...
ORGANISM(S): Zea mays 
2011-05-09 | E-GEOD-29132 | biostudies-arrayexpress
UnknownPreclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition.
Not available
S-EPMC6511062 | biostudies-literature
UnknownCyclin-dependent kinase 12 is a drug target for visceral leishmaniasis.
Not available
S-EPMC6402543 | biostudies-literature
UnknownGeographic Variation in Disease Burden and Mismatch in Care of Patients With Rheumatoid Arthritis in the United States.
Not available
S-EPMC10100689 | biostudies-literature
UnknownIdentification of GSK3186899/DDD853651 as a Preclinical Development Candidate for the Treatment of Visceral Leishmaniasis.
Not available
S-EPMC6407917 | biostudies-literature
UnknownDiscovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma cruzi.
Not available
S-EPMC5601362 | biostudies-literature
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