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MetabolomicsAn ambient-temperature storage and stabilization device performs comparably to flash-frozen collection for stool metabolomics in infants

BACKGROUND: Stool metabolites provide essential insights into the function of the gut microbiome. The current gold standard for storage of stool samples for metabolomics is flash-freezing at - 80 °C which can be inconvenient and expensive. Ambient temperature storage of stool is ...

2021-01-27 | MTBLS201 | MetaboLights
MetabolomicsFecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial

Fecal microbiota transplantation (FMT) represents a potential strategy to overcome resistance to immune checkpoint inhibitors in patients with refractory melanoma; however, the role of FMT in first-line treatment settings has not been evaluated. We conducted a multicenter phase I trial combining ...

2025-02-27 | MTBLS711 | MetaboLights
MetabolomicsA general non-self response as part of plant immunity
Plants, like other multicellular lifeforms, are colonized by microorganisms. How plants respond to their microbiota is currently not well understood. We used a phylogenetically diverse set of 39 endogenous bacterial strains from Arabidopsis thaliana leaves to assess host transcriptional and metaboli...
2021-09-13 | MTBLS2522 | MetaboLights
MetabolomicsATAD3A has a scaffolding role regulating mitochondria inner membrane structure and protein assembly

The ATPase Family AAA Domain Containing 3A (ATAD3A), is a mitochondrial inner membrane protein conserved in metazoans. ATAD3A has been associated with several mitochondrial functions, including nucleoid organization, cholesterol metabolism, and mitochondrial translation. To address its primary ro...

2022-01-14 | MTBLS3786 | MetaboLights
MetabolomicsMetabolic phenotyping of urine from a dementia research cohort
To better understand the molecular mechanisms underpinning physiological variation in human populations, metabolic phenotyping approaches are increasingly being applied to studies involving hundreds and thousands of biofluid samples. Hyphenated ultra-performance liquid chromatography-mass spectromet...
2022-03-01 | MTBLS719 | MetaboLights
TranscriptomicsMap transformed DNA into W6G from VCXB21
Vibrio cholerae isolate W6G transformed with DNA from VCXB21 and selected for chitosan metabolism. Nine independent transformants compared to parental W6G on microarrays containing probes for all N16961 ORFs. Regions acquired from VCXB21 hybridize more strongly to the array. A genotyping experimen...
ORGANISM(S): Vibrio cholerae 
2007-08-16 | E-GEOD-8791 | biostudies-arrayexpress
TranscriptomicsDifferentially expressed genes after treatment with chemotherapy in breast cancer and their correlation with pathologic mid-response (Miller & Payne grade 3)
The aim of this study was to compare the gene expression profile changes breast tumors after the treatment with Anthracyclines and Taxanes. To this end, an oligonucleotide microarray was performed (AffymetrixM-bM-^@M-^Ys HG-U133 Plus 2.0 array). This gene expression study was carried out on the biop...
ORGANISM(S): Homo sapiens 
2012-12-12 | E-GEOD-28583 | biostudies-arrayexpress
GenomicsGenetic Analysis of Limb Malformation Disorders: Miller Syndrome Sequencing Study (LMD-MS)

The overall goal of this project is to investigate the etiology and pathogenesis of malformations (i.e., birth defects) of the limb, concentrating on abnormalities of limb patterning such as limb deficiency/duplications and multiple congenital contractures.

The exome sequences of two s...

phs000244.v1.p1 | EGA
TranscriptomicsGlobal Changes following N-deprivation in Chlamydomonas: 454 sequencing
Chlamydomonas reinhardtii forms lipid droplets rich in triacylglycerols when nutrient-deprived. To begin studying the mechanisms underlying this process, N-deprivation was used to induce triacylglycerol accumulation and changes in developmental programs such as gametogenesis. Comparative global anal...
ORGANISM(S): Chlamydomonas reinhardtii 
2010-09-24 | E-GEOD-24366 | biostudies-arrayexpress
TranscriptomicsToxicity of atrazine and nonylphenol in juvenile rainbow trout (Oncorhynchus mykiss): Effects on general health, disease susceptibility and gene expression
Atrazine (ATZ) and nonylphenol (NP) are commonly identified contaminants in aquatic habitats; however, relatively few studies have considered the impact of these endocrine disrupters on immune function. This study examined the immunotoxicological effects of ATZ and NP at multiple levels of biologic...
ORGANISM(S): Oncorhynchus mykiss 
2012-11-01 | E-GEOD-38726 | biostudies-arrayexpress
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