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MetabolomicsFecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial

Fecal microbiota transplantation (FMT) represents a potential strategy to overcome resistance to immune checkpoint inhibitors in patients with refractory melanoma; however, the role of FMT in first-line treatment settings has not been evaluated. We conducted a multicenter phase I trial combining ...

2025-02-27 | MTBLS711 | MetaboLights
UnknownPhase II trial of trastuzumab in combination with cytotoxic chemotherapy for treatment of metastatic osteosarcoma with human epidermal growth factor receptor 2 overexpression: a report from the children's oncology group.
Not available
S-EPMC3397787 | biostudies-literature
TranscriptomicsComparative genomic hybridization by array of blasts and normal cells from acute myeloid leukemia patients to study germinal copy number variants as potential disease risk factors
Except for the well-known association with Down syndrome, there is little information on the genetic factors predisposing to acute myeloid leukemia. Germinal gene copy-number variations may represent risk factors for the disease. To identify copy number variants present in both normal and leukemic ...
ORGANISM(S): Homo sapiens 
2015-10-01 | E-MTAB-2609 | biostudies-arrayexpress
TranscriptomicsWhole Genome Sequencing Informs Therapeutic Selection for Pancreatic Cancer
Pancreatic cancer remains one of the most lethal of malignancies and a major health burden. We performed whole genome sequencing and CNV analysis of 100 pancreatic ductal adenocarcinomas. Chromosomal rearrangements leading to gene disruption were frequent, affecting genes known to be important in pa...
ORGANISM(S): Homo sapiens 
2015-02-27 | E-GEOD-61502 | biostudies-arrayexpress
TranscriptomicsId2 and Id3 maintain the regulatory T cell pool to suppress inflammatory disease
Regulatory T (Treg) cells suppress the development of inflammatory disease, but our knowledge of transcriptional regulators that control this function remains incomplete. Here we show that expression of Id2 and Id3 in Treg cells was required to suppress development of fatal inflammatory disease. We ...
ORGANISM(S): Mus musculus 
2014-06-29 | E-GEOD-57682 | biostudies-arrayexpress
UnknownLinkage of Alzheimer disease families with Puerto Rican ancestry identifies a chromosome 9 locus.
Not available
S-EPMC8851406 | biostudies-literature
UnknownRecommendations for competing sexual-asexually typified generic names in Sordariomycetes (except Diaporthales, Hypocreales, and Magnaporthales).
Not available
S-EPMC4941682 | biostudies-literature
UnknownDiverging white matter trajectories in children after traumatic brain injury: The RAPBI study.
Not available
S-EPMC5386434 | biostudies-literature
UnknownClinical findings, treatment, and outcomes in cats with naturally occurring hypoadrenocorticism: 41 cases.
Not available
S-EPMC11632852 | biostudies-literature
UnknownRich club analysis in the Alzheimer's disease connectome reveals a relatively undisturbed structural core network.
Not available
S-EPMC4504816 | biostudies-literature
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