Diverging white matter trajectories in children after traumatic brain injury: The RAPBI study.

ABSTRACT:

Objective

To examine longitudinal trajectories of white matter organization in pediatric moderate/severe traumatic brain injury (msTBI) over a 12-month period.

Methods

We studied 21 children (16 M/5 F) with msTBI, assessed 2-5 months postinjury and again 13-19 months postinjury, as well as 20 well-matched healthy control children. We assessed corpus callosum function through interhemispheric transfer time (IHTT), measured using event-related potentials, and related this to diffusion-weighted MRI measures of white matter (WM) microstructure. At the first time point, half of the patients with TBI had significantly slower IHTT (TBI-slow-IHTT, n = 11) and half were in the normal range (TBI-normal-IHTT, n = 10).

Results

The TBI-normal-IHTT group did not differ significantl

SUBMITTER: Dennis EL 

PROVIDER: S-EPMC5386434 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature