White Matter Disruption in Pediatric Traumatic Brain Injury: Results from ENIGMA Pediatric Moderate to Severe Traumatic Brain Injury.

ABSTRACT:

Objective

Our study addressed aims: (1) test the hypothesis that moderate-severe TBI in pediatric patients is associated with widespread white matter (WM) disruption; (2) test the hypothesis that age and sex impact WM organization after injury; and (3) examine associations between WM organization and neurobehavioral outcomes.

Methods

Data from ten previously enrolled, existing cohorts recruited from local hospitals and clinics were shared with the ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) Pediatric msTBI working group. We conducted a coordinated analysis of diffusion MRI (dMRI) data using the ENIGMA dMRI processing pipeline.

Results

Five hundred and seven children and adolescents (244 with complicated mild to severe TBI [msTBI] and 263 controls) w

SUBMITTER: Dennis EL 

PROVIDER: S-EPMC8302152 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature