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MetabolomicsSCP4-STK35/PDIK1L complex is a dual phospho-catalytic signaling dependency in acute myeloid leukemia
Acute myeloid leukemia (AML) cells rely on phospho-signaling pathways to gain unlimited proliferation potential. Here, we used domain-focused CRISPR screening to identify the nuclear phosphatase SCP4 as a dependency in AML, yet this enzyme is dispensable in normal hematopoietic progenitor cells. Usi...
2025-05-29 | MTBLS3707 | MetaboLights
TranscriptomicsImproved transcription and translation with L-leucine stimulation of mTORC1
Roberts syndrome (RBS) is a human developmental disorder caused by mutations in the cohesin acetyltransferase ESCO2. We previously reported that mTORC1 was inhibited and overall translation was reduced in RBS cells. Treatment of RBS cells with L-leucine partially rescued mTOR function and protein sy...
ORGANISM(S): Homo sapiens 
2016-01-15 | E-GEOD-64962 | biostudies-arrayexpress
TranscriptomicsTranscriptional comparison of the filamentous fungus Neurospora crassa growing on three major monosaccharides D-glucose, D-xylose and L-arabinose
D-glucose, D-xylose and L-arabinose are three major monosaccharides in the plant cell wall. Complete utilization of all three sugars is still a bottleneck for second-generation cellulolytic bioethanol production, especially for L-arabinose. However, little is known about the gene expression profiles...
ORGANISM(S): Neurospora crassa 
2014-03-17 | E-GEOD-51091 | biostudies-arrayexpress
MetabolomicsThe effects of oligomycin administration and glutamine deprivation on metabolic profile of MCF7 breast cancer cell line measured using [1,2-13C2]-D-glucose and [U-13C5]-L-glutamine as tracers
This study aims to establish a comprehensive, genome-scale metabolic model (GSMM) combining different omics data of different regulatory levels of breast cancer cells in order to elucidate the way that these regulatory levels affect or determine each other. Together with transcriptomics, proteomics ...
2021-01-18 | MTBLS183 | MetaboLights
TranscriptomicsNext generation sequencing of Coccinella septempunctata L. with non-diapause, diapause, and diapause-terminated states
The most common ladybird beetle, Coccinella septempunctata L., is an excellent predator of crop pests such as aphids and white flies, and it shows a wide range of adaptability, a large appetite and a high reproductive ability. In this study, we collected female adults in three different states, i.e...
ORGANISM(S): Coccinella septempunctata 
2016-06-01 | E-GEOD-75645 | biostudies-arrayexpress
TranscriptomicsImpact of oxidative stress on ascorbate biosynthesis in Chlamydomonas via regulation of the VTC2 gene encoding a GDP-l-galactose phosphorylase
The l-galactose (Smirnoff-Wheeler) pathway represents the major route to l-ascorbic acid (vitamin C) biosynthesis in plants. Arabidopsis thaliana VTC2 and its paralogue VTC5 function as GDP-l-galactose phosphorylases converting GDP-l-galactose to l-galactose-1-P, thus catalyzing the first committed ...
ORGANISM(S): Chlamydomonas reinhardtii 
2012-05-02 | E-GEOD-34826 | biostudies-arrayexpress
ProteomicsComparative membrane-associated proteome of Leishmania (Leishmania) infantum and L.(L.) amazonensis
Protozoan parasites of the genus Leishmania are causative agents of leishmaniasis, a wide range of diseases affecting 12 million people worldwide. The species L. (L.) infantum and L. (L.) amazonensis are causative agents of visceral and cutaneous leishmaniasis, respectively. Most proteome analyses o...
ORGANISM(S): Leishmania infantum JPCM5 Leishmania mexicana 
2022-02-11 | PXD013087 | Pride
Label free proteomics Plasma membrane proteins Leishmania (leishmania) infantum Leishmania (leishmania) amazonensis 
TranscriptomicsRegulation of Transcription Termination by Glucosylated Hydroxymethyluracil, Base J, in L. major and T. brucei
Base J, β-D-glucosyl-hydroxymethyluracil, is an epigenetic modification of thymine in the nuclear DNA of flagellated protozoa of the order Kinetoplastida. J is enriched at sites involved in RNA Polymerase (RNAP) II initiation and termination. We have previously demonstrated a role of J in regulating...
ORGANISM(S): Trypanosoma brucei 
2015-05-18 | E-GEOD-57621 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis reveals season-specific RbcS gene expression profiles in diploid Lolium perenne L.
Perennial ryegrass (Lolium perenne L.) is a major grass species used for forage and turf throughout the world, and gains by conventional breeding have reached a plateau. Perennial ryegrass is an outcrossing, self-incompatible diploid (2n = 2x = 14) with a relatively large genome (4067 Mbp/diploid ge...
ORGANISM(S): Lolium perenne 
2006-11-08 | E-GEOD-5211 | biostudies-arrayexpress
GenomicsL. gongylyphorus transcriptome
Transcriptome of the fungus L. gongylophorus cultivated by the leaf-cutting ant Acromyrmex echinatior
PRJEB4168 | ENA
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